07/24/2025
Research Article
Untangling the role of the two types of dopamine neurons in the dorsomedial striatum in working memory has been challenging due to methodological limitations. Xing-jun Chen, Jiang-fan Chen, Zhihui Li and co-workers show that D2R neurons primarily govern working memory under low cognitive load, while D1R neurons take over when cognitive load increases.
Image credit: pbio.3003289
Current Issue June 2025
07/23/2025
Research Article
Legionella pneumophila pumps hundreds of effector proteins into host cells to hijack cellular processes, including at the mitochondria. Kai-Qi Yek, Hayley Newton, Diana Stojanovski and co-authors show that the effector protein LpPIP is a tail-anchored protein of the mitochondrial outer membrane that recruits Protein Phosphatase 1 to the organelle to modulate the host mitochondrial phosphoproteome.
Image credit: pbio.3003261
07/22/2025
Short Reports
Nitrogen deposition reduces arthropod species richness and abundance, especially in less-modified habitats. Shunxiang Fan, Yunhui Liu and colleagues show that natural and semi-natural habitats can buffer against these losses, emphasizing their conservation value in mitigating nitrogen deposition’s negative effects on arthropod diversity.
Image credit: pbio.3003285
07/22/2025
Research Article
Transport machineries are crucial for antibiotic resistance, but their regulation by external cues is poorly understood. Christoph Binsfeld, Ana Rita Brochado and co-workers identify environmental chemicals that regulate transporter transcription, revealing the transcription factor Rob as a key modulator of efflux pump expression in E. coli.
Image credit: pbio.3003260
07/21/2025
Research Article
Mitochondrial proteins are synthesized with presequences that serve as targeting signals, but why are some more efficient than others? Saskia Rödl, Johannes Herrmann and co-authors identify a group of presequences that endow mitochondrial proteins with prioritized import efficiencies, and show that ‘strong’ presequences recruit Hsp90 and TOMM34 to improve import efficiency.
Image credit: pbio.3003298
07/21/2025
Research Article
The accumulation of aggregated tau shows a complex spatio-temporal pattern during the course of Alzheimer’s disease (AD), but how are these changes orchestrated? This modeling study by Pavanjit Chaggar, Alain Goriely and the Alzheimer’s Disease Neuroimaging Initiative describes tau protein dynamics in AD, revealing stage-specific shifts in its local production and transport.
Image credit: pbio.3003241
07/24/2025
Perspective
This Perspective argues that better preclinical models, understanding of stromal heterogeneity and integration of tumor microenvironment assessments into drug development are needed to improve treatment efficacy.
Image credit: pbio.3003276
07/23/2025
Perspective
Mathematical models have become essential tools for exploring the complex interplay between cancer cells and their microenvironment. This Perspective suggests that AI is leading the way towards the next wave of tumor models.
Image credit: pbio.3003269
07/21/2025
Perspective
This Perspective argues that defining the 3D tumor neural niche using spatial omics and AI technologies could identify new opportunities for targeted therapies to stop cancer progression.
Image credit: pbio.3003266
07/18/2025
Essay
This Essay examines how selection operates across levels, highlighting how we might leverage this understanding to improve cancer research, prevention and treatment.
Image credit: pbio.3003290
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
August 26 - 30
Meet Senior Editor Richard Hodge (rhodge@plos.org)
September 9 - 12
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
September 16 - 19
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
October 5 - 7
Meet Senior Editor Richard Hodge (rhodge@plos.org)
October 7 - 11
Meet Associate Editor Taylor Hart (thart@plos.org)
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