In PLoS Biology, volume 1, issue 1:
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Table 1: In the legend, the words fluxes and flux appeared without the fl.
Table 3: In the legend, the word coefficients appeared without the fi. In the table, some numbers in the section “Binding, dissociation” were marked with a ± sign that should have been a ∓.
Table 4: In the legend, the word coefficients appeared without the fi.
Please see the corrected legends and table below.
Table 1. Numeric Values of Input Quantities of the Model for the Reference State
The data are grouped into concentrations of pathway components, dissociation constants of protein complexes, concentration ratios, fluxes and flux ratios, and characteristic times of selected processes. Experimental evidence for these data is discussed in the text. From these data, the following rates and rate constants are calculated: v12 = 0.42 nM · min−1 (rate of β-catenin synthesis), v14 = 8.2 · 10−5 · nM · min−1 (rate of axin synthesis), k4 = 0.27 min−1, k5 = 0.13 min−1, k6 = 9.1 · 10−2 nM−1 · min−1, k−6 = 0.91 · nM−1 · min−1, k9 = 210 min−1, k10 = 210 min−1, k11 · 0.42 min−1, k13 = 2.6 · 10−4 min−1, k15 = 0.17 · min−1. See Table S2, found at http://dx.doi.org/10.1371/journal.pbio.0000010.t002, for more precise numbers used in the calculations.
Bold: Measured values, Italics: Estimated values.
Table 3. Control Coefficients for the Total Concentrations of β-Catenin and Axin and Parameters Quantifying the Sensitivity and the Robustness of the Wnt/β-Catenin Pathwaydoi:10.1371/journal.pbio.0020089.t001
Table 4. Concentration Control Coefficients for the Total Concentrations of β-Catenin and Axin Relative to Changes in the Concentrations of Pathway Components
The control coefficients were obtained by numerical determination of the response to a change of total concentrations by 1%. Coefficients are given for the reference state and for the standard stimulated state.
The full text XML and HTML versions of the article have been corrected online. This correction note may be found at DOI: 10.1371/journal.pbio.0020089.
Citation: (2004) Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway. PLoS Biol 2(3): e89. doi:10.1371/journal.pbio.0020089
Published: March 16, 2004
Copyright: © 2004 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.