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Research Article

Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent

  • Hye Ji Cha,

    Affiliation: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • Michelle Byrom,

    Affiliation: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • Paul E. Mead,

    Affiliation: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Andrew D. Ellington,

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, United States of America

    X
  • John B. Wallingford mail,

    wallingford@mail.utexas.edu (JBW); marcotte@icmb.utexas.edu (EMM)

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Howard Hughes Medical Institute & Section of Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Edward M. Marcotte mail

    wallingford@mail.utexas.edu (JBW); marcotte@icmb.utexas.edu (EMM)

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, United States of America

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  • Published: August 21, 2012
  • DOI: 10.1371/journal.pbio.1001379

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