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Open Access
Peer-reviewed
Research Article
Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta
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Wenping Zeng ,
Contributed equally to this work with: Wenping Zeng, Canjun Li
Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Canjun Li ,
Contributed equally to this work with: Wenping Zeng, Canjun Li
Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft
Affiliations Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, China
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Ruikun Wu,
Roles Formal analysis, Investigation, Validation
Affiliations Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, China, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Xingguo Yang,
Roles Investigation
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Qingyan Wang,
Roles Investigation
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Bingqian Lin,
Roles Investigation
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Yanan Wei,
Roles Investigation
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Hao Li,
Roles Investigation
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Ge Shan ,
Roles Project administration, Resources
* E-mail: shange@ustc.edu.cn (GS); lilisqu@ustc.edu.cn (LQ); ccang@ustc.edu.cn (CC)
Affiliations Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, China, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Lili Qu ,
Roles Project administration, Supervision, Writing – review & editing
* E-mail: shange@ustc.edu.cn (GS); lilisqu@ustc.edu.cn (LQ); ccang@ustc.edu.cn (CC)
Affiliation Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
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Chunlei Cang
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: shange@ustc.edu.cn (GS); lilisqu@ustc.edu.cn (LQ); ccang@ustc.edu.cn (CC)
Affiliations Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, China, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, Neurodegenerative Disorder Research Center, University of Science and Technology of China, Hefei, Anhui, China
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Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta
- Wenping Zeng,
- Canjun Li,
- Ruikun Wu,
- Xingguo Yang,
- Qingyan Wang,
- Bingqian Lin,
- Yanan Wei,
- Hao Li,
- Ge Shan,
- Lili Qu
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- Published: April 23, 2024
- https://doi.org/10.1371/journal.pbio.3002591