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Research Article

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

  • Simina Grigoriu,

    Affiliations: Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Rachel Bond,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Pilar Cossio,

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jennifer A. Chen,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Nina Ly,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Gerhard Hummer,

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Rebecca Page,

    Affiliation: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Martha S. Cyert mail,

    mcyert@stanford.edu (MSC) (MC); wolfgang_peti@brown.edu (WP) (WP)

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Wolfgang Peti mail

    mcyert@stanford.edu (MSC) (MC); wolfgang_peti@brown.edu (WP) (WP)

    Affiliations: Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America, Department of Chemistry, Brown University, Providence, Rhode Island, United States of America

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  • Published: February 26, 2013
  • DOI: 10.1371/journal.pbio.1001492

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