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Research Article

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

  • Amandine Girousse,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Geneviève Tavernier,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Carine Valle,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Cedric Moro,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Niklas Mejhert,

    Affiliation: Department of Medicine, Karolinska Institute at Karolinska Hospital, Huddinge, Stockholm, Sweden

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  • Anne-Laure Dinel,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

    X
  • Marianne Houssier,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Balbine Roussel,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Aurèle Besse-Patin,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Marion Combes,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Lucile Mir,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Laurent Monbrun,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Véronic Bézaire,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

    X
  • Bénédicte Prunet-Marcassus,

    Affiliation: Physiogenex, Prologue Biotech, Labège-Innopole, France

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  • Aurélie Waget,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048,Team 2, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Isabelle Vila,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Sylvie Caspar-Bauguil,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France, Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France

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  • Katie Louche,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

    X
  • Marie-Adeline Marques,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

    X
  • Aline Mairal,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

    X
  • Marie-Laure Renoud,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

    X
  • Jean Galitzky,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Cecilia Holm,

    Affiliation: Department of Experimental Medical Science, Lund University, Lund, Sweden

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  • Etienne Mouisel,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

    X
  • Claire Thalamas,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France, Toulouse University Hospitals, INSERM, Clinical Investigation Center, Toulouse, France

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  • Nathalie Viguerie,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Thierry Sulpice,

    Affiliation: Physiogenex, Prologue Biotech, Labège-Innopole, France

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  • Rémy Burcelin,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048,Team 2, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Peter Arner,

    Affiliation: Department of Medicine, Karolinska Institute at Karolinska Hospital, Huddinge, Stockholm, Sweden

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  • Dominique Langin mail

    dominique.langin@inserm.fr

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France, Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France

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  • Published: February 19, 2013
  • DOI: 10.1371/journal.pbio.1001485

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