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Research Article

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

  • Ruohan Xia,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Hongge Jia,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Junkai Fan,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Yajuan Liu,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Jianhang Jia mail

    Jianhang.jia@uky.edu

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Published: January 10, 2012
  • DOI: 10.1371/journal.pbio.1001238

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