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Research Article

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

  • Donatella Valdembri,

    Affiliation: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy

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  • Patrick T Caswell,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Kurt I Anderson,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Juliane P Schwarz,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Ireen König,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Elena Astanina,

    Affiliation: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy

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  • Francesca Caccavari,

    Affiliation: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy

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  • Jim C Norman,

    Affiliation: Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom

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  • Martin J Humphries,

    Affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Federico Bussolino,

    Affiliations: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy, Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy

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  • Guido Serini mail

    To whom correspondence should be addressed. E-mail: guido.serini@ircc.it

    Affiliations: Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy, Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy

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  • Published: January 27, 2009
  • DOI: 10.1371/journal.pbio.1000025

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