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Research Article

High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

  • Kevin A Wilkinson,

    Affiliation: Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Robert J Gorelick,

    Affiliation: AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute-Fredrick, Frederick, Maryland, United States of America

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  • Suzy M Vasa,

    Affiliation: Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Nicolas Guex,

    Affiliation: Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Alan Rein,

    Affiliation: HIV Drug Resistance Program, National Cancer Institute-Fredrick, Frederick, Maryland, United States of America

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  • David H Mathews,

    Affiliation: Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, United States of America

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  • Morgan C Giddings,

    Affiliations: Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Kevin M Weeks mail

    To whom correspondence should be addressed. E-mail: weeks@unc.edu

    Affiliation: Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Published: April 29, 2008
  • DOI: 10.1371/journal.pbio.0060096

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