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Research Article

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

  • Maojun Yang,

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Bing Li,

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Chyong-Jy Liu,

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Diana R Tomchick,

    Affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Mischa Machius,

    Affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Josep Rizo,

    Affiliations: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Hongtao Yu mail,

    To whom correspondence should be addressed. E-mail: hongtao.yu@utsouthwestern.edu (HY); xuelian.luo@utsouthwestern.edu (XL)

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Xuelian Luo mail

    To whom correspondence should be addressed. E-mail: hongtao.yu@utsouthwestern.edu (HY); xuelian.luo@utsouthwestern.edu (XL)

    Affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Published: March 04, 2008
  • DOI: 10.1371/journal.pbio.0060050

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