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Research Article

The p75 Neurotrophin Receptor Is a Central Regulator of Glioma Invasion

  • Angela L. M Johnston,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada

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  • Xueqing Lun,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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  • Jennifer J Rahn,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada

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  • Abdelhamid Liacini,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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  • Limei Wang,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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  • Mark G Hamilton,

    Affiliations: Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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  • Ian F Parney,

    Affiliations: Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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  • Barbara L Hempstead,

    Affiliation: Division of Hematology, Cornell University Medical College, New York, New York, United States of America

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  • Stephen M Robbins,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada

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  • Peter A Forsyth mail,

    To whom correspondence should be addressed. E-mail: pforsyth@ucalgary.ca (PAF); senger@ucalgary.ca (DLS)

    Affiliations: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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  • Donna L Senger mail

    To whom correspondence should be addressed. E-mail: pforsyth@ucalgary.ca (PAF); senger@ucalgary.ca (DLS)

    Affiliations: Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada, Clark H. Smith Integrative Brain Tumour Research Center, Calgary, Alberta, Canada, Department of Oncology, University of Calgary, Calgary, Alberta, Canada

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  • Published: August 14, 2007
  • DOI: 10.1371/journal.pbio.0050212

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