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Research Article

Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

  • Daniel A Kraut,

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Paul A Sigala,

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Brandon Pybus,

    Affiliation: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Corey W Liu,

    Affiliation: Stanford Magnetic Resonance Laboratory, Stanford University, Stanford, California, United States of America

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  • Dagmar Ringe,

    Affiliation: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Gregory A Petsko,

    Affiliation: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Daniel Herschlag mail

    To whom correspondence should be addressed. E-mail: herschla@stanford.edu

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

    X
  • Published: March 28, 2006
  • DOI: 10.1371/journal.pbio.0040099

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