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Research Article

T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression

  • Jeroen P Roose,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • Maximilian Diehn,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Michael G Tomlinson,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • Joseph Lin,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • Ash A Alizadeh,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

    ¤1Present address: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • David Botstein,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    ¤2Present address: Lewis-Sigler Institute, Princeton University, Princeton, New Jersey, United States of America

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  • Patrick O Brown,

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Arthur Weiss mail

    To whom correspondence should be addressed. E-mail: aweiss@medicine.ucsf.edu

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, United States of America, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: November 17, 2003
  • DOI: 10.1371/journal.pbio.0000053

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