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Research Article

TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

  • Anna Śledzińska,

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Saskia Hemmers,

    Affiliation: Institute for Genetics, University of Cologne, Cologne, Germany

    Current address: Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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  • Florian Mair,

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Oliver Gorka,

    Affiliation: Clinical Chemistry, Klinikum rechts der Isar, Technische Universität München, Germany

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  • Jürgen Ruland,

    Affiliation: Clinical Chemistry, Klinikum rechts der Isar, Technische Universität München, Germany

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  • Lynsey Fairbairn,

    Affiliation: Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Germany

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  • Anja Nissler,

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Werner Müller,

    Affiliation: Department of Experimental Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany

    Current address: Bill Ford Chair of Cellular Immunology, Faculty of Life Science, University of Manchester, Manchester, United Kingdom.

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  • Ari Waisman,

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Institute for Molecular Medicine, University Medical Center of the Johannes-Gutenberg University of Mainz, Mainz, Germany

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  • Burkhard Becher equal contributor mail,

    equal contributor Contributed equally to this work with: Burkhard Becher, Thorsten Buch

    Thorsten.Buch@mikrobio.med.tum.de (TB); becher@immunology.uzh.ch (BB)

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Thorsten Buch equal contributor mail

    equal contributor Contributed equally to this work with: Burkhard Becher, Thorsten Buch

    Thorsten.Buch@mikrobio.med.tum.de (TB); becher@immunology.uzh.ch (BB)

    Affiliations: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland, Institute for Genetics, University of Cologne, Cologne, Germany, Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Germany

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  • Published: October 08, 2013
  • DOI: 10.1371/journal.pbio.1001674

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