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Research Article

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

  • Roza Selimyan,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Rachel M. Gerstein,

    Affiliation: Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Irina Ivanova,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Patricia Precht,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Ramesh Subrahmanyam,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Thomas Perlot,

    Affiliation: The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria

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  • Frederick W. Alt,

    Affiliation: The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ranjan Sen mail

    senranja@grc.nia.nih.gov

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Published: January 29, 2013
  • DOI: 10.1371/journal.pbio.1001475

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