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Research Article

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

  • Maria Kalyuga ,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    DGO and MK contributed equally to this work and are joint first authors.

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  • David Gallego-Ortega ,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    DGO and MK contributed equally to this work and are joint first authors.

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  • Heather J. Lee,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Daniel L. Roden,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Mark J. Cowley,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • C. Elizabeth Caldon,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Andrew Stone,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Stephanie L. Allerdice,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Fatima Valdes-Mora,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Rosalind Launchbury,

    Affiliation: Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

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  • Aaron L. Statham,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Nicola Armstrong,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, School of Mathematics and Statistics, and Prince of Wales Clinical School, University of New South Wales Kensington NSW, Australia

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  • M. Chehani Alles,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Adelaide Young,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, University of Bath, Bath, United Kingdom

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  • Andrea Egger,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Wendy Au,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Catherine L. Piggin,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Cara J. Evans,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Anita Ledger,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Tilman Brummer,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    Current address: Institute for Molecular Medicine and Cell Research, Freiburg, Germany

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  • Samantha R. Oakes,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Warren Kaplan,

    Affiliations: Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Julia M. W. Gee,

    Affiliation: Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom

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  • Robert I. Nicholson,

    Affiliation: Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom

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  • Robert L. Sutherland †,

    † Deceased.

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Alexander Swarbrick,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Matthew J. Naylor,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia, Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, NSW, Australia

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  • Susan J. Clark,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Jason S. Carroll,

    Affiliation: Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

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  • Christopher J. Ormandy mail

    c.ormandy@garvan.org.au

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pbio.1001461

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