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Research Article

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium

  • Ken S. Lau,

    Affiliations: Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Virna Cortez-Retamozo,

    Affiliation: Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Sarah R. Philips,

    Affiliations: Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Mikael J. Pittet,

    Affiliation: Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Douglas A. Lauffenburger,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Kevin M. Haigis mail

    khaigis@partners.org

    Affiliations: Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: September 25, 2012
  • DOI: 10.1371/journal.pbio.1001393

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