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Research Article

The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

  • Niels H. Gehring mail,

    Niels.Gehring@med.uni-heidelberg.de (NHG); Andreas.Kulozik@med.uni-heidelberg.de (AEK)

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Styliani Lamprinaki,

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Matthias W. Hentze,

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

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  • Andreas E. Kulozik mail

    Niels.Gehring@med.uni-heidelberg.de (NHG); Andreas.Kulozik@med.uni-heidelberg.de (AEK)

    Affiliations: Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000120

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