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Research Article

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

  • Christophe Kunz,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Frauke Focke,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Yusuke Saito,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • David Schuermann,

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Teresa Lettieri,

    Affiliation: Institute of Cell Biology, ETH Zürich, Zürich, Switzerland

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  • Jim Selfridge,

    Affiliation: Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, Scotland

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  • Primo Schär mail

    To whom correspondence should be addressed. E-mail: primo.schaer@unibas.ch

    Affiliation: Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Published: April 28, 2009
  • DOI: 10.1371/journal.pbio.1000091

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