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Research Article

A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

  • Patrick E MacDonald mail,

    To whom correspondence should be addressed. E-mail: pmacdonald@bcell.org

    Affiliations: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Yang Zhang De Marinis,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

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  • Reshma Ramracheya,

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Albert Salehi,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

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  • Xiaosong Ma,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

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  • Paul R. V Johnson,

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Roger Cox,

    Affiliation: Medical Research Council Mammalian Genetics Unit, Harwell, United Kingdom

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  • Lena Eliasson,

    Affiliation: Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden

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  • Patrik Rorsman

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Published: May 15, 2007
  • DOI: 10.1371/journal.pbio.0050143

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