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Research Article

Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

  • João F Passos,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Gabriele Saretzki,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Shaheda Ahmed,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Glyn Nelson,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Torsten Richter,

    Affiliation: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Heiko Peters,

    Affiliation: Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Ilka Wappler,

    Affiliation: Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Matthew J Birket,

    Affiliation: School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Graham Harold,

    Affiliation: Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Karin Schaeuble,

    Affiliation: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Mark A Birch-Machin,

    Affiliation: School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Thomas B. L Kirkwood,

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Thomas von Zglinicki mail

    To whom correspondence should be addressed. E-mail: t.vonzglinicki@ncl.ac.uk

    Affiliations: Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom

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  • Published: May 01, 2007
  • DOI: 10.1371/journal.pbio.0050110

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