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Research Article

Oxygenation Inhibits the Physiological Tissue-Protecting Mechanism and Thereby Exacerbates Acute Inflammatory Lung Injury

  • Manfred Thiel,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Clinic of Anaesthesiology, University of Munich, Germany

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  • Alexander Chouker,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Clinic of Anaesthesiology, University of Munich, Germany

    X
  • Akio Ohta,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

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  • Edward Jackson,

    Affiliation: Pharmacology/Medicine Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, United States of America

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  • Charles Caldwell,

    Affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Patrick Smith,

    Affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Dmitry Lukashev,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

    X
  • Iris Bittmann,

    Affiliation: Pathology, Klinikum Grosshadern, University of Munich, Germany

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  • Michail V Sitkovsky mail

    To whom correspondence should be addressed. E-mail: m.sitkovsky@neu.edu

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

    X
  • Published: May 03, 2005
  • DOI: 10.1371/journal.pbio.0030174

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