Table of Contents | January 2007

About This Image

A mouse with Cockayne syndrome.

Artist impression of the Csb/Xpa mouse model for the progeroid DNA repair disorder Cockayne syndrome. This animal model shows dwarf growth, neurological abnormalities, aging-associated pathology, and premature death. A comparison of the transcriptome of normal and mutant mouse livers revealed a novel link between genome instability and the age-related decline of the somatotroph axis (see van der Pluijm et al., e2).

Image Credit: Image by Ingrid van der Pluijm

Synopses

Manipulating Cellular pH Suggests Novel Anticancer Therapy

Liza Gross

A Simple Feedback Resistor Switch Keeps Latent HIV from Awakening

Richard Robinson

The Neural Cascade of Attentional Control

Janelle Weaver

Essay

Evolution, Interactions, and Biological Networks

Joshua S Weitz, Philip N Benfey, Ned S Wingreen

Feature

Stem Cell Promise, Interrupted: How Long Do US Researchers Have to Wait?

Liza Gross

Research Articles

Alternative 3′ Pre-mRNA Processing in Saccharomyces cerevisiae Is Modulated by Nab4/Hrp1 In Vivo

Karen S. Kim Guisbert, Hao Li, Christine Guthrie

Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

Ingrid van der Pluijm, George A Garinis, Renata M. C Brandt, Theo G. M. F Gorgels, Susan W Wijnhoven, Karin E. M Diderich, Jan de Wit, James R Mitchell, Conny van Oostrom, Rudolf Beems, Laura J Niedernhofer, Susana Velasco, Errol C Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst

DNA Damage–Induced Bcl-x_L Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH

Rui Zhao, David Oxley, Trevor S Smith, George A Follows, Anthony R Green, Denis R Alexander

Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles

Jeremiah J Faith, Boris Hayete, Joshua T Thaden, Ilaria Mogno, Jamey Wierzbowski, Guillaume Cottarel, Simon Kasif, James J Collins, Timothy S Gardner

Correspondence

Author Sequence and Credit for Contributions in Multiauthored Publications

Teja Tscharntke, Michael E Hochberg, Tatyana A Rand, Vincent H Resh, Jochen Krauss

Corrections

Correction: Interdigitated Paralemniscal and Lemniscal Pathways in the Mouse Barrel Cortex

Ingrid Bureau, Francisca von Saint Paul, Karel Svoboda

Correction: Asymmetrical Reinforcement and Wolbachia Infection in Drosophila

John Jaenike, Kelly Dyer, Chad Cornish, Miranda Minhas