Table of Contents | June 2005

About This Image

A malarial sporozoite in an infected epithelial cell.

Malaria is transmitted to people and animals by mosquitoes. Malarial sporozoites develop inside oocysts and are released in large numbers into the hemocoel of Anopheles stephensi mosquitoes. This false-colored electron micrograph shows a sporozoite migrating through the cytoplasm of midgut epithelia. See Frevert et al.

Image Credit: Image by Ute Frevert; false color by Margaret Shear

Essay

The Evolution of Norms

Paul R Ehrlich, Simon A Levin

Feature

Functional Genomics Thickens the Biological Plot

Virginia Gewin

Book Review/Science in the Media

A Hymn to Neurosurgery and Neuroscience

Richard Smith

Primers

Pseudoknots: RNA Structures with Diverse Functions

David W Staple, Samuel E Butcher

When Two Is Better Than One: Elements of Intravital Microscopy

David W Piston

Community Page

Guidelines for Negotiating Scientific Collaboration

Neil R Smalheiser, Guy A Perkins, Steve Jones

Research Articles

On the Number of New World Founders: A Population Genetic Portrait of the Peopling of the Americas

Jody Hey

A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees

Rasmus Nielsen, Carlos Bustamante, Andrew G Clark, Stephen Glanowski, Timothy B Sackton, Melissa J Hubisz, Adi Fledel-Alon, David M Tanenbaum, Daniel Civello, Thomas J White, John J. Sninsky, Mark D Adams, Michele Cargill

A New Yeast Poly(A) Polymerase Complex Involved in RNA Quality Control

Štěpánka Vaňáčová, Jeannette Wolf, Georges Martin, Diana Blank, Sabine Dettwiler, Arno Friedlein, Hanno Langen, Gérard Keith, Walter Keller

RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons

Vladimir V Kapitonov, Jerzy Jurka

A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift Signal

Ewan P Plant, Gabriela C Pérez-Alvarado, Jonathan L Jacobs, Bani Mukhopadhyay, Mirko Hennig, Jonathan D Dinman

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance

Ryan T Cirz, Jodie K Chin, David R Andes, Valérie de Crécy-Lagard, William A Craig, Floyd E Romesberg

Intravital Observation of Plasmodium berghei Sporozoite Infection of the Liver

Ute Frevert, Sabine Engelmann, Sergine Zougbédé, Jörg Stange, Bruce Ng, Kai Matuschewski, Leonard Liebes, Herman Yee

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Takaharu Okada, Mark J Miller, Ian Parker, Matthew F Krummel, Margaret Neighbors, Suzanne B Hartley, Anne O'Garra, Michael D Cahalan, Jason G Cyster

Directed Migration of Positively Selected Thymocytes Visualized in Real Time

Colleen M Witt, Subhadip Raychaudhuri, Brian Schaefer, Arup K Chakraborty, Ellen A Robey

Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation

Nathalie E Blachère, Robert B Darnell, Matthew L Albert

Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation

Yang Chao, Eric N Shiozaki, Srinivasa M Srinivasula, Daniel J Rigotti, Robert Fairman, Yigong Shi

Oxygenation Inhibits the Physiological Tissue-Protecting Mechanism and Thereby Exacerbates Acute Inflammatory Lung Injury

Manfred Thiel, Alexander Chouker, Akio Ohta, Edward Jackson, Charles Caldwell, Patrick Smith, Dmitry Lukashev, Iris Bittmann, Michail V Sitkovsky

Determination of Stromal Signatures in Breast Carcinoma

Robert B West, Dimitry S. A Nuyten, Subbaya Subramanian, Torsten O Nielsen, Christopher L Corless, Brian P Rubin, Kelli Montgomery, Shirley Zhu, Rajiv Patel, Tina Hernandez-Boussard, John R Goldblum, Patrick O Brown, Marc van de Vijver, Matt van de Rijn

Correction

Correction: As the Antarctic Ice Pack Recedes, a Fragile Ecosystem Hangs in the Balance

Liza Gross