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Editorial
Essay
Features
Unsolved Mystery
Book Review/Science in the Media
Journal Club
Primers
Community Page
Research Articles
Corrections

Table of Contents | December 2003

About This Image

Structure of the water-selective aquaporin AqpZ.

The cover depicts the structure of the newly-discovered, water-selective aquaporin AqpZ. Five water molecules are seen in the channel defining the conductance pathway. The painting represents a merging of science and mythology in which AqpZ traverses a membrane "sea" between the cytoplasmic underworld and an approaching rainstorm. (See Savage, et al.)

Image Credit: Painting by Julie Newdoll, www.brushwithscience.com. Ribbons created with PyMOL software

Editorial

A Changing Landscape

Helen Doyle, Andy Gass, Debra Lappin

Essay

The Virus That Changed My World

Lisa Fong Poh Ng

Features

Economy of the Mind

Kendall Powell

Human Epigenome Project—Up and Running

Jane Bradbury

Unsolved Mystery

How Are the Sizes of Cells, Organs, and Bodies Controlled?

Ernst Hafen, Hugo Stocker

Book Review/Science in the Media

Rose-Tinted Ecology

Thomas Brooks

Journal Club

A Wingless Flight

Xiang Yu

Primers

How Mammals Acquire and Distribute Iron Needed for Oxygen-Based Metabolism

Tracey A Rouault

Antigen-Specific T Cells: Analyses of the Needles in the Haystack

Jill E Slansky

Community Page

Research Advocacy: Why Every Scientist Should Participate

Elizabeth Marincola

Research Articles

Architecture and Selectivity in Aquaporins: 2.5 Å X-Ray Structure of Aquaporin Z

David F Savage, Pascal F Egea, Yaneth Robles-Colmenares, Joseph D. O'Connell III, Robert M Stroud

Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor

Anthony M Giannetti, Peter M Snow, Olga Zak, Pamela J Björkman

Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2

Unnur Styrkarsdottir, Jean-Baptiste Cazier, Augustine Kong, Ottar Rolfsson, Helene Larsen, Emma Bjarnadottir, Vala D Johannsdottir, Margret S Sigurdardottir, Yu Bagger, Claus Christiansen, Inga Reynisdottir, Struan F. A Grant, Kristjan Jonasson, Michael L Frigge, Jeffrey R Gulcher, Gunnar Sigurdsson, Kari Stefansson

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity

Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, Karin Séron, Lynn Bekris, Janice Cabellon, Bernadette Neve, Valérie Vasseur-Delannoy, Mohamed Chikri, M. Aline Charles, Karine Clement, Ake Lernmark, Philippe Froguel

Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells

Prabhat S Kunwar, Michelle Starz-Gaiano, Roland J Bainton, Ulrike Heberlein, Ruth Lehmann

Pten Dose Dictates Cancer Progression in the Prostate

Lloyd C Trotman, Masaru Niki, Zohar A Dotan, Jason A Koutcher, Antonio Di Cristofano, Andrew Xiao, Alan S Khoo, Pradip Roy-Burman, Norman M Greenberg, Terry Van Dyke, Carlos Cordon-Cardo, Pier Paolo Pandolfi

Identification of Drosophila MicroRNA Targets

Alexander Stark, Julius Brennecke, Robert B Russell, Stephen M Cohen

Transcriptome Analysis of Mouse Stem Cells and Early Embryos

Alexei A Sharov, Yulan Piao, Ryo Matoba, Dawood B Dudekula, Yong Qian, Vincent VanBuren, Geppino Falco, Patrick R Martin, Carole A Stagg, Uwem C Bassey, Yuxia Wang, Mark G Carter, Toshio Hamatani, Kazuhiro Aiba, Hidenori Akutsu, Lioudmila Sharova, Tetsuya S Tanaka, Wendy L Kimber, Toshiyuki Yoshikawa, Saied A Jaradat, Serafino Pantano, Ramaiah Nagaraja, Kenneth R Boheler, Dennis Taub, Richard J Hodes, Dan L Longo, David Schlessinger, Jonathan Keller, Emily Klotz, Garnett Kelsoe, Akihiro Umezawa, Angelo L Vescovi, Janet Rossant, Tilo Kunath, Brigid L. M Hogan, Anna Curci, Michele D'Urso, Janet Kelso, Winston Hide, Minoru S. H Ko

Corrections

Correction: What Controls Variation in Human Skin Color?

Gregory S Barsh

Correction: Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action

Inês Barroso, Jian'an Luan, Rita P. S Middelberg, Anne-Helen Harding, Rupert W Jakes, David Clayton, Alan J Schafer, Stephen O'Rahilly, Nicholas J Wareham