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Table of Contents | October 2003

About This Image

Borneo elephants, a genetically distinct taxon native to Borneo.

The cover shows native Borneo elephants, which are now recognized as genetically distinct from other Asian elephants. The Borneo elephants are therefore a high priority for conservation. (See Fernando, et al.)

Image Credit: Photograph kindly provided by Cede Prudente, World Wildlife Fund, Malaysia

Message from the Founders

Why PLoS Became a Publisher

Patrick O Brown, Michael B Eisen, Harold E Varmus

Editorial

PLoS Biology—We're Open

Philip Bernstein, Barbara Cohen, Catriona MacCallum, Hemai Parthasarathy, Mark Patterson, Vivian Siegel

Essay

Neuroscience Networks

Thomas R Insel, Nora D Volkow, Ting-Kai Li, James F Battey Jr, Story C Landis

Features

Digital Evolution

Bill O'Neill

Genetically Modified Corn— Environmental Benefits and Risks

Virginia Gewin

Unsolved Mystery

What Controls Variation in Human Skin Color?

Gregory S Barsh

Journal Club

Heterochromatin Dynamics

Tobias Straub

Primers

V(D)J Recombination and the Evolution of the Adaptive Immune System

Eleonora Market, F. Nina Papavasiliou

Microarray Analysis

Greg Gibson

Community Page

Out of the Way

Glenn Otis Brown

Research Articles

Drosophila Free-Running Rhythms Require Intercellular Communication

Ying Peng, Dan Stoleru, Joel D Levine, Jeffrey C Hall, Michael Rosbash

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action

Inês Barroso, Jian'an Luan, Rita P. S Middelberg, Anne-Helen Harding, Paul W Franks, Rupert W Jakes, David Clayton, Alan J Schafer, Stephen O'Rahilly, Nicholas J Wareham

A Functional Analysis of the Spacer of V(D)J Recombination Signal Sequences

Alfred Ian Lee, Sebastian D Fugmann, Lindsay G Cowell, Leon M Ptaszek, Garnett Kelsoe, David G Schatz

Developmental Origin and Evolution of Bacteriocytes in the Aphid–Buchnera Symbiosis

Christian Braendle, Toru Miura, Ryan Bickel, Alexander W Shingleton, Srinivas Kambhampati, David L Stern

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

Femke Simmer, Celine Moorman, Alexander M van der Linden, Ewart Kuijk, Peter V.E van den Berghe, Ravi S Kamath, Andrew G Fraser, Julie Ahringer, Ronald H. A Plasterk

The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum

Zbynek Bozdech, Manuel Llinás, Brian Lee Pulliam, Edith D Wong, Jingchun Zhu, Joseph L DeRisi

From Gene Trees to Organismal Phylogeny in Prokaryotes:The Case of the γ-Proteobacteria

Emmanuelle Lerat, Vincent Daubin, Nancy A Moran

DNA Analysis Indicates That Asian Elephants Are Native to Borneo and Are Therefore a High Priority for Conservation

Prithiviraj Fernando, T. N. C Vidya, John Payne, Michael Stuewe, Geoffrey Davison, Raymond J Alfred, Patrick Andau, Edwin Bosi, Annelisa Kilbourn, Don J Melnick

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W Kirschner