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Table of Contents: June 2011

COVER

A scanning electron micrograph of a single coccolithophore cell.

Image Credit: Alison R. Taylor (University of North Carolina Wilmington Microscopy Facility)
Issue Image

Coccolithophores such as Emiliania huxleyi shown here are single-celled marine phytoplankton that produce calcium carbonate scales (coccoliths). They occur in all of the world’s oceans and together represent the largest source of biogenic calcium carbonate on Earth, contributing significantly to the global carbon cycle. Coccoliths, which are produced inside the cells, are secreted to the cell surface. The discovery of proton channels in the coccolithophore cell membrane provides new insight into how they cope with excess protons generated during calcification and will inform future studies of how these important organisms will respond to ocean acidification (see Taylor et al., e1001085).

Synopses

Unsolved Mystery

Why Are Autism Spectrum Conditions More Prevalent in Males?

Simon Baron-Cohen, Michael V. Lombardo, Bonnie Auyeung, Emma Ashwin, Bhismadev Chakrabarti, Rebecca Knickmeyer

Historical and Philosophical Perspectives

The Mismeasure of Science: Stephen Jay Gould versus Samuel George Morton on Skulls and Bias

Jason E. Lewis, David DeGusta, Marc R. Meyer, Janet M. Monge, Alan E. Mann, Ralph L. Holloway

Book Review/Science in the Media

Primer

Community Page

The Genomic Standards Consortium

Dawn Field, Linda Amaral-Zettler, Guy Cochrane, James R. Cole, Peter Dawyndt, George M. Garrity, Jack Gilbert, Frank Oliver Glöckner, Lynette Hirschman, Ilene Karsch-Mizrachi, Hans-Peter Klenk, Rob Knight, Renzo Kottmann, Nikos Kyrpides, Folker Meyer, Inigo San Gil, Susanna-Assunta Sansone, Lynn M. Schriml, Peter Sterk, Tatiana Tatusova, David W. Ussery, Owen White, John Wooley

Research Articles

The Neural Basis of Following Advice

Guido Biele, Jörg Rieskamp, Lea K. Krugel, Hauke R. Heekeren

Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

Kirsi H. Pietiläinen, Tomasz Róg, Tuulikki Seppänen-Laakso, Sam Virtue, Peddinti Gopalacharyulu, Jing Tang, Sergio Rodriguez-Cuenca, Arkadiusz Maciejewski, Jussi Naukkarinen, Anna-Liisa Ruskeepää, Perttu S. Niemelä, Laxman Yetukuri, Chong Yew Tan, Vidya Velagapudi, Sandra Castillo, Heli Nygren, Tuulia Hyötyläinen, Aila Rissanen, Jaakko Kaprio, Hannele Yki-Järvinen, Ilpo Vattulainen, Antonio Vidal-Puig, Matej Orešič

phot1 Inhibition of ABCB19 Primes Lateral Auxin Fluxes in the Shoot Apex Required For Phototropism

John M. Christie, Haibing Yang, Gregory L. Richter, Stuart Sullivan, Catriona E. Thomson, Jinshan Lin, Boosaree Titapiwatanakun, Margaret Ennis, Eirini Kaiserli, Ok Ran Lee, Jiri Adamec, Wendy A. Peer, Angus S. Murphy

A Voltage-Gated H+ Channel Underlying pH Homeostasis in Calcifying Coccolithophores

Alison R. Taylor, Abdul Chrachri, Glen Wheeler, Helen Goddard, Colin Brownlee

The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway

Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon, Jean-François Moreau, Paul Hofman, Pierre Vacher, Patrick Legembre

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe, Jin Jiang

Zyxin Links Fat Signaling to the Hippo Pathway

Cordelia Rauskolb, Guohui Pan, B. V. V. G. Reddy, Hyangyee Oh, Kenneth D. Irvine

Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State

Lisa Prendergast, Chelly van Vuuren, Agnieszka Kaczmarczyk, Volker Doering, Daniela Hellwig, Nadine Quinn, Christian Hoischen, Stephan Diekmann, Kevin F. Sullivan

Patterns and Mechanisms of Ancestral Histone Protein Inheritance in Budding Yeast

Marta Radman-Livaja, Kitty F. Verzijlbergen, Assaf Weiner, Tibor van Welsem, Nir Friedman, Oliver J. Rando, Fred van Leeuwen

Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output

Barbara Celona, Assaf Weiner, Francesca Di Felice, Francesco M. Mancuso, Elisa Cesarini, Riccardo L. Rossi, Lorna Gregory, Dilair Baban, Grazisa Rossetti, Paolo Grianti, Massimiliano Pagani, Tiziana Bonaldi, Jiannis Ragoussis, Nir Friedman, Giorgio Camilloni, Marco E. Bianchi, Alessandra Agresti

Towards a Pharmacophore for Amyloid

Meytal Landau, Michael R. Sawaya, Kym F. Faull, Arthur Laganowsky, Lin Jiang, Stuart A. Sievers, Jie Liu, Jorge R. Barrio, David Eisenberg