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Table of Contents: December 2010

COVER

A look through the fly eye at receptor turnover during brain wiring.

Image Credit: Ryan Williamson and Robin Hiesinger, UT Southwestern Medical Center, United States of America
Issue Image

In this issue of PLoS Biology, Williamson et al., e1000553, propose that a neuron-specific protein degradation pathway is required for the spatiotemporal regulation of guidance receptors during development of the Drosophila visual system. The picture shows a preparation of the eye of the fruit fly, Drosophila melanogaster. The eye is imaged from the inside and fluorescently labeled for the light sensitive rhabdomeres using Phalloidin. A confocal maximum projection visualization was false-colored to distinguish rhabdomere cross-sections (center, blue) from tangential sections (orange). The Drosophila eye forms a stereotyped pattern during development and extends axons into the brain using specialized guidance cues.

Synopses

Essay

How Can Vaccines Against Influenza and Other Viral Diseases Be Made More Effective?

Peter L. Nara, Gregory J. Tobin, A. Ray Chaudhuri, Jessie D. Trujillo, George Lin, Michael W. Cho, Simon A. Levin, Wilfred Ndifon, Ned S. Wingreen

Book Review

Neuro Nonsense

Ben A. Barres

Research Articles

Genomic DNA Sequences from Mastodon and Woolly Mammoth Reveal Deep Speciation of Forest and Savanna Elephants

Nadin Rohland, David Reich, Swapan Mallick, Matthias Meyer, Richard E. Green, Nicholas J. Georgiadis, Alfred L. Roca, Michael Hofreiter

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

Tsuyoshi Hirota, Jae Wook Lee, Warren G. Lewis, Eric E. Zhang, Ghislain Breton, Xianzhong Liu, Michael Garcia, Eric C. Peters, Jean-Pierre Etchegaray, David Traver, Peter G. Schultz, Steve A. Kay

Stress-Induced Out-of-Context Activation of Memory

Karel Ježek, Benjamin B. Lee, Eduard Kelemen, Katharine M. McCarthy, Bruce S. McEwen, André A. Fenton

Melanopsin Contributions to Irradiance Coding in the Thalamo-Cortical Visual System

Timothy M. Brown, Carlos Gias, Megumi Hatori, Sheena R. Keding, Ma'ayan Semo, Peter J. Coffey, John Gigg, Hugh D. Piggins, Satchidananda Panda, Robert J. Lucas

A Novel Neural Substrate for the Transformation of Olfactory Inputs into Motor Output

Dominique Derjean, Aimen Moussaddy, Elias Atallah, Melissa St-Pierre, François Auclair, Steven Chang, Xiang Ren, Barbara Zielinski, Réjean Dubuc

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

Guo-Jen Huang, Adrian L. Smith, Daniel H.D. Gray, Cormac Cosgrove, Benjamin H. Singer, Andrew Edwards, Stuart Sim, Jack M. Parent, Alyssa Johnsen, Richard Mott, Diane Mathis, Paul Klenerman, Christophe Benoist, Jonathan Flint

Guidance Receptor Degradation Is Required for Neuronal Connectivity in the Drosophila Nervous System

W. Ryan Williamson, Taehong Yang, Jonathan R. Terman, P. Robin Hiesinger

Prox1 Regulates the Notch1-Mediated Inhibition of Neurogenesis

Valeria Kaltezioti, Georgia Kouroupi, Maria Oikonomaki, Evangelia Mantouvalou, Athanasios Stergiopoulos, Aristidis Charonis, Hermann Rohrer, Rebecca Matsas, Panagiotis K. Politis

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

Tobias Steinfeldt, Stephanie Könen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L. David Sibley, Julia P. Hunn, Jonathan C. Howard

HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

Merel Gijsen, Peter King, Tim Perera, Peter J. Parker, Adrian L. Harris, Banafshé Larijani, Anthony Kong

Connecting Variability in Global Transcription Rate to Mitochondrial Variability

Ricardo Pires das Neves, Nick S. Jones, Lorena Andreu, Rajeev Gupta, Tariq Enver, Francisco J. Iborra

Domain Swapping in Allosteric Modulation of DNA Specificity

Chad K. Park, Hemant K. Joshi, Alka Agrawal, M. Imran Ghare, Elizabeth J. Little, Pete W. Dunten, Jurate Bitinaite, Nancy C. Horton

Structure of a Classical MHC Class I Molecule That Binds “Non-Classical” Ligands

Chee Seng Hee, Song Gao, Bernhard Loll, Marcia M. Miller, Barbara Uchanska-Ziegler, Oliver Daumke, Andreas Ziegler