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Table of Contents: April 2010

COVER

Dramatic separation of the centrosomes and the nucleus in dynein-depleted human cells at the onset of mitosis.

Image Credit: Marvin Tanenbaum, Department of Medical Oncology and Cancer Genomics Center, University Medical Center, Utrecht, The Netherlands
Issue Image

A cell depleted of the dynein-heavy chain and stained for microtubules (green), centrosomes (red), and DNA (blue). Dynein activity at the nuclear envelope keeps the centrosomes closely tethered to the nucleus during mitotic entry. In the absence of dynein, centrosomes and the nucleus are actively displaced to opposite sides of the cell as a result of the antagonistic activity of kinesin-1, pushing the centrosomes and the nucleus apart (see Splinter et al., e1000350).

Synopsis

Essay

Perspective

Research Articles

Proteorhodopsin Phototrophy Promotes Survival of Marine Bacteria during Starvation

Laura Gómez-Consarnau, Neelam Akram, Kristoffer Lindell, Anders Pedersen, Richard Neutze, Debra L. Milton, José M. González, Jarone Pinhassi

Carbon Dioxide Sensing Modulates Lifespan and Physiology in Drosophila

Peter C. Poon, Tsung-Han Kuo, Nancy J. Linford, Gregg Roman, Scott D. Pletcher

Environmental Change Enhances Cognitive Abilities in Fish

Alexander Kotrschal, Barbara Taborsky

Cholinergic Activation of M2 Receptors Leads to Context-Dependent Modulation of Feedforward Inhibition in the Visual Thalamus

Miklos Antal, Claudio Acuna-Goycolea, R. Todd Pressler, Dawn M. Blitz, Wade G. Regehr

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons

Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R. Kramer, Wolfgang Wurst, Rüdiger Klein

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

Marta Gómez-Gonzalo, Gabriele Losi, Angela Chiavegato, Micaela Zonta, Mario Cammarota, Marco Brondi, Francesco Vetri, Laura Uva, Tullio Pozzan, Marco de Curtis, Gian Michele Ratto, Giorgio Carmignoto

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design

Jean Mazella, Olivier Pétrault, Guillaume Lucas, Emmanuel Deval, Sophie Béraud-Dufour, Carine Gandin, Malika El-Yacoubi, Catherine Widmann, Alice Guyon, Eric Chevet, Said Taouji, Grégory Conductier, Alain Corinus, Thierry Coppola, Gabriella Gobbi, Jean-Louis Nahon, Catherine Heurteaux, Marc Borsotto

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

Daniël Splinter, Marvin E. Tanenbaum, Arne Lindqvist, Dick Jaarsma, Annette Flotho, Ka Lou Yu, Ilya Grigoriev, Dieuwke Engelsma, Elize D. Haasdijk, Nanda Keijzer, Jeroen Demmers, Maarten Fornerod, Frauke Melchior, Casper C. Hoogenraad, René H. Medema, Anna Akhmanova

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

Daniel J. Gough, Nicole L. Messina, Linda Hii, Jodee A. Gould, Kanaga Sabapathy, Ashley P. S. Robertson, Joseph A. Trapani, David E. Levy, Paul J. Hertzog, Christopher J. P. Clarke, Ricky W. Johnstone

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

Rong Shi, Ariane Proteau, Magda Villarroya, Ismaïl Moukadiri, Linhua Zhang, Jean-François Trempe, Allan Matte, M. Eugenia Armengod, Miroslaw Cygler