Table of Contents | October 2009

About This Image

Worker females guarding the nest entrance of a honeybee colony.

Each colony has thousands of female workers, one queen, and a few hundred males (drones). This strong sex bias relies on an unusual sex determination system. Gempe et al. (e1000222) show key functions for the regulation of two genes: csd, which establishes the decision between males and females by allelic combination, and fem, which memorizes the sexual decision by a positive regulatory feedback loop that operates throughout development.

Image Credit: Björn Schmitt, Heinrich-Heine-Universität Düsseldorf

Editorial

Genomics of Emerging Infectious Disease: A PLoS Collection

Jonathan A. Eisen, Catriona J. MacCallum

Synopses

Male or Female? For Honeybees, a Single Gene Makes All the Difference

Mary Hoff

Serotonin's Role in the Pancreas Revealed at Last

Richard Robinson

Neurons Help Bridge the Brain's Communication Gap

Rachel Jones

Perspectives

Can an Infectious Disease Genomics Project Predict and Prevent the Next Pandemic?

Rajesh Gupta, Mark H. Michalski, Frank R. Rijsberman

The Role of Genomics in the Identification, Prediction, and Prevention of Biological Threats

W. Florian Fricke, David A. Rasko, Jacques Ravel

Primers

Linking Inflammation to Natural Killer T Cell Activation

Mariolina Salio, Vincenzo Cerundolo

Heterochromatin: A Rapidly Evolving Species Barrier

Stacie E. Hughes, R. Scott Hawley

Research Articles

Sex Determination in Honeybees: Two Separate Mechanisms Induce and Maintain the Female Pathway

Tanja Gempe, Martin Hasselmann, Morten Schiøtt, Gerd Hause, Marianne Otte, Martin Beye

Transient Neuronal Populations Are Required to Guide Callosal Axons: A Role for Semaphorin 3C

Mathieu Niquille, Sonia Garel, Fanny Mann, Jean-Pierre Hornung, Belkacem Otsmane, Sébastien Chevalley, Carlos Parras, Francois Guillemot, Patricia Gaspar, Yuchio Yanagawa, Cécile Lebrand

Dynamic Coupling of Pattern Formation and Morphogenesis in the Developing Vertebrate Retina

Alexander Picker, Florencia Cavodeassi, Anja Machate, Sabine Bernauer, Stefan Hans, Gembu Abe, Koichi Kawakami, Stephen W. Wilson, Michael Brand

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

Nils Paulmann, Maik Grohmann, Jörg-Peter Voigt, Bettina Bert, Jakob Vowinckel, Michael Bader, Maša Skelin, Marko Jevšek, Heidrun Fink, Marjan Rupnik, Diego J. Walther

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

Peter W. Janes, Sabine H. Wimmer-Kleikamp, Achilleas S. Frangakis, Kane Treble, Bettina Griesshaber, Ola Sabet, Markus Grabenbauer, Alice Y. Ting, Paul Saftig, Philippe I. Bastiaens, Martin Lackmann

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

Lisa M. Fox, Daryl G. Cox, Jennifer L. Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L. Trott, Rachel M. Ndonye, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Mark E. Cook, Erin J. Adams, William H. Hildebrand, Jenny E. Gumperz

Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth

David A. Davis, Meredith H. Wilson, Jodel Giraud, Zhigang Xie, Huang-Chun Tseng, Cheryl England, Haya Herscovitz, Li-Huei Tsai, Ivana Delalle

Species-Specific Heterochromatin Prevents Mitotic Chromosome Segregation to Cause Hybrid Lethality in Drosophila

Patrick M. Ferree, Daniel A. Barbash

Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics

Zhihua Li, Insuk Lee, Emily Moradi, Nai-Jung Hung, Arlen W. Johnson, Edward M. Marcotte

Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins

Raffi Tonikian, Xiaofeng Xin, Christopher P. Toret, David Gfeller, Christiane Landgraf, Simona Panni, Serena Paoluzi, Luisa Castagnoli, Bridget Currell, Somasekar Seshagiri, Haiyuan Yu, Barbara Winsor, Marc Vidal, Mark B. Gerstein, Gary D. Bader, Rudolf Volkmer, Gianni Cesareni, David G. Drubin, Philip M. Kim, Sachdev S. Sidhu, Charles Boone