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Table of Contents: June 2009

COVER

Yeast aquaporin gating.

Image Credit: Urszula Kosinska-Eriksson, Gerhard Fischer (University of Gothenburg).
Issue Image

An article in the June issue of PLoS Biology reports the crystal structure of a gated aquaporin from yeast at the highest resolution so far obtained for a membrane protein (see Fischer et al., e1000130). At this resolution it is possible to view the specific orientation of water molecules as they pass through the channel and to see how the co-transport of protons is excluded. The structure reveals that yeast aquaporins are gated, providing an energetically economical solution to the need to respond to the numerous stresses associated with rapidly changing environments, aiding the organism's quest to survive.

Synopses

Unsolved Mystery

The Hedgehog Signaling Pathway: Where Did It Come From?

George Hausmann, Christian von Mering, Konrad Basler

Book Review/Science in the Media

Mind the Gap!

Antonio Lazcano

Primers

Parks and Tourism

Ralf Buckley

Research Articles

A Global Perspective on Trends in Nature-Based Tourism

Andrew Balmford, James Beresford, Jonathan Green, Robin Naidoo, Matt Walpole, Andrea Manica

Management Effectiveness of the World's Marine Fisheries

Camilo Mora, Ransom A. Myers, Marta Coll, Simone Libralato, Tony J. Pitcher, Rashid U. Sumaila, Dirk Zeller, Reg Watson, Kevin J. Gaston, Boris Worm

Allometry of the Duration of Flight Feather Molt in Birds

Sievert Rohwer, Robert E. Ricklefs, Vanya G. Rohwer, Michelle M. Copple

Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice

Jessica W. Tsai, Jens Hannibal, Grace Hagiwara, Damien Colas, Elisabeth Ruppert, Norman F. Ruby, H. Craig Heller, Paul Franken, Patrice Bourgin

Long-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity

Amir Minerbi, Roni Kahana, Larissa Goldfeld, Maya Kaufman, Shimon Marom, Noam E. Ziv

Positional Cues in the Drosophila Nerve Cord: Semaphorins Pattern the Dorso-Ventral Axis

Marta Zlatic, Feng Li, Maura Strigini, Wesley Grueber, Michael Bate

Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)

Elisabetta Menna, Andrea Disanza, Cinzia Cagnoli, Ursula Schenk, Giuliana Gelsomino, Emanuela Frittoli, Maud Hertzog, Nina Offenhauser, Corinna Sawallisch, Hans-Jürgen Kreienkamp, Frank B. Gertler, Pier Paolo Di Fiore, Giorgio Scita, Michela Matteoli

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

Hasan Korkaya, Amanda Paulson, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Marty Brown, Julie Dutcher, Shawn G. Clouthier, Max S. Wicha

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

Zahra Kadri, Ritsuko Shimizu, Osamu Ohneda, Leila Maouche-Chretien, Sylvie Gisselbrecht, Masayuki Yamamoto, Paul-Henri Romeo, Philippe Leboulch, Stany Chretien

Plant Insecticide L-Canavanine Repels Drosophila via the Insect Orphan GPCR DmX

Christian Mitri, Laurent Soustelle, Bérénice Framery, Joël Bockaert, Marie-Laure Parmentier, Yves Grau

RIN4 Functions with Plasma Membrane H+-ATPases to Regulate Stomatal Apertures during Pathogen Attack

Jun Liu, James M. Elmore, Anja T. Fuglsang, Michael G. Palmgren, Brian J. Staskawicz, Gitta Coaker

Turning Meiosis into Mitosis

Isabelle d'Erfurth, Sylvie Jolivet, Nicole Froger, Olivier Catrice, Maria Novatchkova, Raphaël Mercier

Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species

Pedro Beltrao, Jonathan C. Trinidad, Dorothea Fiedler, Assen Roguev, Wendell A. Lim, Kevan M. Shokat, Alma L. Burlingame, Nevan J. Krogan

Biofilm Matrix Regulation by Candida albicans Zap1

Clarissa J. Nobile, Jeniel E. Nett, Aaron D. Hernday, Oliver R. Homann, Jean-Sebastien Deneault, Andre Nantel, David R. Andes, Alexander D. Johnson, Aaron P. Mitchell

Self-Organization of the Escherichia coli Chemotaxis Network Imaged with Super-Resolution Light Microscopy

Derek Greenfield, Ann L. McEvoy, Hari Shroff, Gavin E. Crooks, Ned S. Wingreen, Eric Betzig, Jan Liphardt

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Elton Zeqiraj, Beatrice Maria Filippi, Simon Goldie, Iva Navratilova, Jérôme Boudeau, Maria Deak, Dario R. Alessi, Daan M. F. van Aalten

Crystal Structure of a Yeast Aquaporin at 1.15 Å Reveals a Novel Gating Mechanism

Gerhard Fischer, Urszula Kosinska-Eriksson, Camilo Aponte-Santamaría, Madelene Palmgren, Cecilia Geijer, Kristina Hedfalk, Stefan Hohmann, Bert L. de Groot, Richard Neutze, Karin Lindkvist-Petersson