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Table of Contents: May 2009

COVER

Finishing the mouse genome.

Image Credit: Jennifer Torrance (Multimedia Services, The Jackson Laboratory).
Issue Image

An article published in the May issue of PLoS Biology reports on the completion of the mouse genome (see Church et al., e1000112). This genome assembly was constructed from a single inbred stain, C57BL/6J (featured in the center of the photo). A more-complete genome assembly reveals not only how mice differ from humans, but also shows how various strains can differ from each other.

Synopsis

Feature

Book Review/Science in the Media

Primer

Research Articles

Skin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma

Shadmehr Demehri, Mitsuru Morimoto, Michael J. Holtzman, Raphael Kopan

Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse

Deanna M. Church, Leo Goodstadt, LaDeana W. Hillier, Michael C. Zody, Steve Goldstein, Xinwe She, Carol J. Bult, Richa Agarwala, Joshua L. Cherry, Michael DiCuccio, Wratko Hlavina, Yuri Kapustin, Peter Meric, Donna Maglott, Zoë Birtle, Ana C. Marques, Tina Graves, Shiguo Zhou, Brian Teague, Konstantinos Potamousis, Christopher Churas, Michael Place, Jill Herschleb, Ron Runnheim, Daniel Forrest, James Amos-Landgraf, David C. Schwartz, Ze Cheng, Kerstin Lindblad-Toh, Evan E. Eichler, Chris P. Ponting , The Mouse Genome Sequencing Consortium

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

Mark E. Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Drew M. Lowery, Karl R. Clauser, Chao Zhang, Kevan M. Shokat, Steven A. Carr, Michael B. Yaffe, Prasad V. Jallepalli

Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

Jinglan Liu, Zhe Zhang, Masashige Bando, Takehiko Itoh, Matthew A. Deardorff, Dinah Clark, Maninder Kaur, Stephany Tandy, Tatsuro Kondoh, Eric Rappaport, Nancy B. Spinner, Hugo Vega, Laird G. Jackson, Katsuhiko Shirahige, Ian D. Krantz

Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin

Yongli Shan, Lihou Yu, Yan Li, Youdong Pan, Qiangge Zhang, Fubin Wang, Jianfeng Chen, Xueliang Zhu

Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure

Yakov Korkhin, Ulug M Unligil, Otis Littlefield, Pamlea J Nelson, David I Stuart, Paul B Sigler, Stephen D Bell, Nicola G. A Abrescia

Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors

Youichi Shinozaki, Koji Sumitomo, Makoto Tsuda, Schuichi Koizumi, Kazuhide Inoue, Keiichi Torimitsu