Table of Contents: February 2007


Crystal structure of the SV40 T-antigen origin binding domain.

Image Credit: Image by Gretchen Meinke
Issue Image

The crystal structure of the origin-binding domain of simian virus T-antigen on DNA shows that the protein domains do not contact one another when bound to the origin. Straight, B-form DNA (orange) has been aligned with the nucleotide bases on the left side of the figure to highlight the DNA deformations in the protein complex (see Meinke et al., e23).


Open Access to Research Is in the Public Interest

Bevin P Engelward, Richard J Roberts



Evolution by Any Other Name: Antibiotic Resistance and Avoidance of the E-Word

Janis Antonovics, Jessica L Abbate, Christi Howell Baker, Douglas Daley, Michael E Hood, Christina E Jenkins, Louise J Johnson, James J Murray, Vijay Panjeti, Volker H. W Rudolf, Dan Sloan, Joanna Vondrasek

Research Articles

The Crystal Structure of the SV40 T-Antigen Origin Binding Domain in Complex with DNA

Gretchen Meinke, Paul Phelan, Stephanie Moine, Elena Bochkareva, Alexey Bochkarev, Peter A Bullock, Andrew Bohm

Different Quaternary Structures of Human RECQ1 Are Associated with Its Dual Enzymatic Activity

Laura Muzzolini, Fabienne Beuron, Ardan Patwardhan, Venkateswarlu Popuri, Sheng Cui, Benedetta Niccolini, Mathieu Rappas, Paul S Freemont, Alessandro Vindigni

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Stefan Floess, Jennifer Freyer, Christiane Siewert, Udo Baron, Sven Olek, Julia Polansky, Kerstin Schlawe, Hyun-Dong Chang, Tobias Bopp, Edgar Schmitt, Stefan Klein-Hessling, Edgar Serfling, Alf Hamann, Jochen Huehn

System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

Benoît Kornmann, Olivier Schaad, Hermann Bujard, Joseph S Takahashi, Ueli Schibler

Discrete States of a Protein Interaction Network Govern Interphase and Mitotic Microtubule Dynamics

Philipp Niethammer, Iva Kronja, Stefanie Kandels-Lewis, Sonja Rybina, Philippe Bastiaens, Eric Karsenti

Intermolecular Failure of L-type Ca2+ Channel and Ryanodine Receptor Signaling in Hypertrophy

Ming Xu, Peng Zhou, Shi-Ming Xu, Yin Liu, Xinheng Feng, Shu-Hua Bai, Yan Bai, Xue-Mei Hao, Qide Han, Youyi Zhang, Shi-Qiang Wang

Pre-Steady-State Decoding of the Bicoid Morphogen Gradient

Sven Bergmann, Oded Sandler, Hila Sberro, Sara Shnider, Eyal Schejter, Ben-Zion Shilo, Naama Barkai

Hsp104-Dependent Remodeling of Prion Complexes Mediates Protein-Only Inheritance

Prasanna Satpute-Krishnan, Sara X Langseth, Tricia R Serio

Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements

Ji-Ann Lee, Yi Xing, David Nguyen, Jiuyong Xie, Christopher J Lee, Douglas L Black

Specification of Neuronal Identities by Feedforward Combinatorial Coding

Magnus Baumgardt, Irene Miguel-Aliaga, Daniel Karlsson, Helen Ekman, Stefan Thor

Active Spatial Perception in the Vibrissa Scanning Sensorimotor System

Samar B Mehta, Diane Whitmer, Rodolfo Figueroa, Ben A Williams, David Kleinfeld

Shifts in Coding Properties and Maintenance of Information Transmission during Adaptation in Barrel Cortex

Miguel Maravall, Rasmus S Petersen, Adrienne L Fairhall, Ehsan Arabzadeh, Mathew E Diamond

Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates

Hurng-Yi Wang, Huan-Chieh Chien, Naoki Osada, Katsuyuki Hashimoto, Sumio Sugano, Takashi Gojobori, Chen-Kung Chou, Shih-Feng Tsai, Chung-I Wu, C.-K. James Shen

Splicing and the Evolution of Proteins in Mammals

Joanna L Parmley, Araxi O Urrutia, Lukasz Potrzebowski, Henrik Kaessmann, Laurence D Hurst

The Costs of Carnivory

Chris Carbone, Amber Teacher, J. Marcus Rowcliffe