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Table of Contents: December 2003

COVER

Structure of the water-selective aquaporin AqpZ.

Image Credit: Painting by Julie Newdoll, www.brushwithscience.com. Ribbons created with PyMOL software
Issue Image

The cover depicts the structure of the newly-discovered, water-selective aquaporin AqpZ. Five water molecules are seen in the channel defining the conductance pathway. The painting represents a merging of science and mythology in which AqpZ traverses a membrane "sea" between the cytoplasmic underworld and an approaching rainstorm. (See Savage, et al.)

Editorial

A Changing Landscape

Helen Doyle, Andy Gass, Debra Lappin

Essay

Features

Economy of the Mind

Kendall Powell

Unsolved Mystery

Book Review/Science in the Media

Rose-Tinted Ecology

Thomas Brooks

Journal Club

Community Page

Research Articles

Architecture and Selectivity in Aquaporins: 2.5 Å X-Ray Structure of Aquaporin Z

David F Savage, Pascal F Egea, Yaneth Robles-Colmenares, Joseph D. O'Connell III, Robert M Stroud

Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2

Unnur Styrkarsdottir, Jean-Baptiste Cazier, Augustine Kong, Ottar Rolfsson, Helene Larsen, Emma Bjarnadottir, Vala D Johannsdottir, Margret S Sigurdardottir, Yu Bagger, Claus Christiansen, Inga Reynisdottir, Struan F. A Grant, Kristjan Jonasson, Michael L Frigge, Jeffrey R Gulcher, Gunnar Sigurdsson, Kari Stefansson

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity

Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, Karin Séron, Lynn Bekris, Janice Cabellon, Bernadette Neve, Valérie Vasseur-Delannoy, Mohamed Chikri, M. Aline Charles, Karine Clement, Ake Lernmark, Philippe Froguel

Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells

Prabhat S Kunwar, Michelle Starz-Gaiano, Roland J Bainton, Ulrike Heberlein, Ruth Lehmann

Pten Dose Dictates Cancer Progression in the Prostate

Lloyd C Trotman, Masaru Niki, Zohar A Dotan, Jason A Koutcher, Antonio Di Cristofano, Andrew Xiao, Alan S Khoo, Pradip Roy-Burman, Norman M Greenberg, Terry Van Dyke, Carlos Cordon-Cardo, Pier Paolo Pandolfi

Identification of Drosophila MicroRNA Targets

Alexander Stark, Julius Brennecke, Robert B Russell, Stephen M Cohen

Transcriptome Analysis of Mouse Stem Cells and Early Embryos

Alexei A Sharov, Yulan Piao, Ryo Matoba, Dawood B Dudekula, Yong Qian, Vincent VanBuren, Geppino Falco, Patrick R Martin, Carole A Stagg, Uwem C Bassey, Yuxia Wang, Mark G Carter, Toshio Hamatani, Kazuhiro Aiba, Hidenori Akutsu, Lioudmila Sharova, Tetsuya S Tanaka, Wendy L Kimber, Toshiyuki Yoshikawa, Saied A Jaradat, Serafino Pantano, Ramaiah Nagaraja, Kenneth R Boheler, Dennis Taub, Richard J Hodes, Dan L Longo, David Schlessinger, Jonathan Keller, Emily Klotz, Garnett Kelsoe, Akihiro Umezawa, Angelo L Vescovi, Janet Rossant, Tilo Kunath, Brigid L. M Hogan, Anna Curci, Michele D'Urso, Janet Kelso, Winston Hide, Minoru S. H Ko

Detection and Characterizationof Cellular Immune Responses Using Peptide–MHC Microarrays

Yoav Soen, Daniel S Chen, Daniel L Kraft, Mark M Davis, Patrick O Brown

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

Keiichi Kondo, William Y Kim, Mirna Lechpammer, William G Kaelin Jr

Corrections

Correction: Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action

Inês Barroso, Jian'an Luan, Rita P. S Middelberg, Anne-Helen Harding, Rupert W Jakes, David Clayton, Alan J Schafer, Stephen O'Rahilly, Nicholas J Wareham