Table of Contents: May 2012


Artistic rendering of the conformational polymorphism of a neurotoxic protein.

Image Credit: Àngel Gómez-Sicilia, Albert Galera-Prat, and Mariano Carrón-Vázquez. Image generated using CESGA resources and VMD program.
Issue Image

Neurodegenerative diseases like Alzheimer's or Parkinson's have been causally related to specific proteins that typically do not have a defined structure. Using single-molecule force spectroscopy one can monitor their rich conformational polymorphism, which is on the basis of the key process that triggers the pathological cascade, making it an ideal target for therapy, diagnostics and prevention. This conformational polymorphism is closely associated to disease and can be inhibited by a potential therapeutic agent. See Hervás et al. (e1001335), in this issue.



Book Review/Science in the Media


Adaptive Evolution in Ecological Communities

Martin M. Turcotte, Michael S. C. Corrin, Marc T. J. Johnson

Community Page

Dealing with Data: A Case Study on Information and Data Management Literacy

Melissa A. Haendel, Nicole A. Vasilevsky, Jacqueline A. Wirz

Research Articles

Species Interactions Alter Evolutionary Responses to a Novel Environment

Diane Lawrence, Francesca Fiegna, Volker Behrends, Jacob G. Bundy, Albert B. Phillimore, Thomas Bell, Timothy G. Barraclough

A Genetic Basis for Mechanosensory Traits in Humans

Henning Frenzel, Jörg Bohlender, Katrin Pinsker, Bärbel Wohlleben, Jens Tank, Stefan G. Lechner, Daniela Schiska, Teresa Jaijo, Franz Rüschendorf, Kathrin Saar, Jens Jordan, José M. Millán, Manfred Gross, Gary R. Lewin

Mechanisms and Evolutionary Patterns of Mammalian and Avian Dosage Compensation

Philippe Julien, David Brawand, Magali Soumillon, Anamaria Necsulea, Angélica Liechti, Frédéric Schütz, Tasman Daish, Frank Grützner, Henrik Kaessmann

Common Features at the Start of the Neurodegeneration Cascade

Rubén Hervás, Javier Oroz, Albert Galera-Prat, Oscar Goñi, Alejandro Valbuena, Andrés M. Vera, Àngel Gómez-Sicilia, Fernando Losada-Urzáiz, Vladimir N. Uversky, Margarita Menéndez, Douglas V. Laurents, Marta Bruix, Mariano Carrión-Vázquez

The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans

Berangere Pinan-Lucarre, Christopher V. Gabel, Christopher P. Reina, S. Elizabeth Hulme, Sergey S. Shevkoplyas, R. Daniel Slone, Jian Xue, Yujie Qiao, Sarah Weisberg, Kevin Roodhouse, Lin Sun, George M. Whitesides, Aravinthan Samuel, Monica Driscoll

Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex

Man Jiang, Jie Zhu, Yaping Liu, Mingpo Yang, Cuiping Tian, Shan Jiang, Yonghong Wang, Hui Guo, Kaiyan Wang, Yousheng Shu

Competing Sound Sources Reveal Spatial Effects in Cortical Processing

Ross K. Maddox, Cyrus P. Billimoria, Ben P. Perrone, Barbara G. Shinn-Cunningham, Kamal Sen

Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation

Tomas Garzon-Muvdi, Paula Schiapparelli, Colette ap Rhys, Hugo Guerrero-Cazares, Christopher Smith, Deok-Ho Kim, Lyonell Kone, Harrison Farber, Danielle Y. Lee, Steven S. An, Andre Levchenko, Alfredo Quiñones-Hinojosa

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

Weiqin Lu, Yumin Hu, Gang Chen, Zhao Chen, Hui Zhang, Feng Wang, Li Feng, Helene Pelicano, Hua Wang, Michael J. Keating, Jinsong Liu, Wallace McKeehan, Huamin Wang, Yongde Luo, Peng Huang