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Table of Contents: February 2012

COVER

Multicellular rosette in a post-implantation mouse embryo.

Image Credit: Natalia White and Shankar Srinivas
Issue Image

This opacity rendering shows a confocal image volume of a 5.5 dpc mouse embryo. The embryo has been stained for the tight junction marker ZO-1 (white), which delineates the apical outlines of cells of the visceral endoderm, a simple epithelium that forms the surface of the embryo. Nuclei are stained with DAPI (blue). Rosettes are groups or five or more cells that share a common central vertex. The individual cells of a seven-cell rosette have been segmented in contrasting colors. See Trichas, et al. (e1001256).

Synopses

Making Magnetic Yeast

Stephanie Huang

Essay

Book Review/Science in the Media

Obituary

Primers

Research Articles

Patterns of Gene Flow Define Species of Thermophilic Archaea

Hinsby Cadillo-Quiroz, Xavier Didelot, Nicole L. Held, Alfa Herrera, Aaron Darling, Michael L. Reno, David J. Krause, Rachel J. Whitaker

Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection

James W. Kijas, Johannes A. Lenstra, Ben Hayes, Simon Boitard, Laercio R. Porto Neto, Magali San Cristobal, Bertrand Servin, Russell McCulloch, Vicki Whan, Kimberly Gietzen, Samuel Paiva, William Barendse, Elena Ciani, Herman Raadsma, John McEwan, Brian Dalrymple , other members of the International Sheep Genomics Consortium

Multi-Cellular Rosettes in the Mouse Visceral Endoderm Facilitate the Ordered Migration of Anterior Visceral Endoderm Cells

Georgios Trichas, Aaron M. Smith, Natalia White, Vivienne Wilkins, Tomoko Watanabe, Abigail Moore, Bradley Joyce, Jacintha Sugnaseelan, Tristan A. Rodriguez, David Kay, Ruth E. Baker, Philip K. Maini, Shankar Srinivas

Movement-Related Theta Rhythm in Humans: Coordinating Self-Directed Hippocampal Learning

Raphael Kaplan, Christian F. Doeller, Gareth R. Barnes, Vladimir Litvak, Emrah Düzel, Peter A. Bandettini, Neil Burgess

Neural Mechanisms Underlying Motivation of Mental Versus Physical Effort

Liane Schmidt, Maël Lebreton, Marie-Laure Cléry-Melin, Jean Daunizeau, Mathias Pessiglione

Facilitation of AMPA Receptor Synaptic Delivery as a Molecular Mechanism for Cognitive Enhancement

Shira Knafo, César Venero, Cristina Sánchez-Puelles, Inmaculada Pereda-Peréz, Ana Franco, Carmen Sandi, Luz M. Suárez, José M. Solís, Lidia Alonso-Nanclares, Eduardo D. Martín, Paula Merino-Serrais, Erika Borcel, Shizhong Li, Yongshuo Chen, Juncal Gonzalez-Soriano, Vladimir Berezin, Elisabeth Bock, Javier DeFelipe, José A. Esteban

Astrocytes Mediate In Vivo Cholinergic-Induced Synaptic Plasticity

Marta Navarrete, Gertrudis Perea, David Fernandez de Sevilla, Marta Gómez-Gonzalo, Angel Núñez, Eduardo D. Martín, Alfonso Araque

p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells

Abhinav K. Jain, Kendra Allton, Michelina Iacovino, Elisabeth Mahen, Robert J. Milczarek, Thomas P. Zwaka, Michael Kyba, Michelle Craig Barton

Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines

Hiroshi Watarai, Etsuko Sekine-Kondo, Tomokuni Shigeura, Yasutaka Motomura, Takuwa Yasuda, Rumi Satoh, Hisahiro Yoshida, Masato Kubo, Hiroshi Kawamoto, Haruhiko Koseki, Masaru Taniguchi

Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties

Nikos Pinotsis, Spyros D. Chatziefthimiou, Felix Berkemeier, Fabienne Beuron, Irene M. Mavridis, Petr V. Konarev, Dmitri I. Svergun, Edward Morris, Matthias Rief, Matthias Wilmanns

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

Kim Debacker, Aisling Frizzell, Olive Gleeson, Lucy Kirkham-McCarthy, Tony Mertz, Robert S. Lahue