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Table of Contents: October 2009

COVER

Worker females guarding the nest entrance of a honeybee colony.

Image Credit: Björn Schmitt, Heinrich-Heine-Universität Düsseldorf
Issue Image

Each colony has thousands of female workers, one queen, and a few hundred males (drones). This strong sex bias relies on an unusual sex determination system. Gempe et al. (e1000222) show key functions for the regulation of two genes: csd, which establishes the decision between males and females by allelic combination, and fem, which memorizes the sexual decision by a positive regulatory feedback loop that operates throughout development.

Editorial

Genomics of Emerging Infectious Disease: A PLoS Collection

Jonathan A. Eisen, Catriona J. MacCallum

Synopses

Perspectives

Primers

Heterochromatin: A Rapidly Evolving Species Barrier

Stacie E. Hughes, R. Scott Hawley

Research Articles

Sex Determination in Honeybees: Two Separate Mechanisms Induce and Maintain the Female Pathway

Tanja Gempe, Martin Hasselmann, Morten Schiøtt, Gerd Hause, Marianne Otte, Martin Beye

Transient Neuronal Populations Are Required to Guide Callosal Axons: A Role for Semaphorin 3C

Mathieu Niquille, Sonia Garel, Fanny Mann, Jean-Pierre Hornung, Belkacem Otsmane, Sébastien Chevalley, Carlos Parras, Francois Guillemot, Patricia Gaspar, Yuchio Yanagawa, Cécile Lebrand

Dynamic Coupling of Pattern Formation and Morphogenesis in the Developing Vertebrate Retina

Alexander Picker, Florencia Cavodeassi, Anja Machate, Sabine Bernauer, Stefan Hans, Gembu Abe, Koichi Kawakami, Stephen W. Wilson, Michael Brand

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

Nils Paulmann, Maik Grohmann, Jörg-Peter Voigt, Bettina Bert, Jakob Vowinckel, Michael Bader, Maša Skelin, Marko Jevšek, Heidrun Fink, Marjan Rupnik, Diego J. Walther

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

Peter W. Janes, Sabine H. Wimmer-Kleikamp, Achilleas S. Frangakis, Kane Treble, Bettina Griesshaber, Ola Sabet, Markus Grabenbauer, Alice Y. Ting, Paul Saftig, Philippe I. Bastiaens, Martin Lackmann

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

Lisa M. Fox, Daryl G. Cox, Jennifer L. Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L. Trott, Rachel M. Ndonye, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Mark E. Cook, Erin J. Adams, William H. Hildebrand, Jenny E. Gumperz

Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth

David A. Davis, Meredith H. Wilson, Jodel Giraud, Zhigang Xie, Huang-Chun Tseng, Cheryl England, Haya Herscovitz, Li-Huei Tsai, Ivana Delalle

Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics

Zhihua Li, Insuk Lee, Emily Moradi, Nai-Jung Hung, Arlen W. Johnson, Edward M. Marcotte

Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins

Raffi Tonikian, Xiaofeng Xin, Christopher P. Toret, David Gfeller, Christiane Landgraf, Simona Panni, Serena Paoluzi, Luisa Castagnoli, Bridget Currell, Somasekar Seshagiri, Haiyuan Yu, Barbara Winsor, Marc Vidal, Mark B. Gerstein, Gary D. Bader, Rudolf Volkmer, Gianni Cesareni, David G. Drubin, Philip M. Kim, Sachdev S. Sidhu, Charles Boone

Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation

Giuseppina Giglia-Mari, Arjan F. Theil, Pierre-Olivier Mari, Sophie Mourgues, Julie Nonnekens, Lise O. Andrieux, Jan de Wit, Catherine Miquel, Nils Wijgers, Alex Maas, Maria Fousteri, Jan H. J. Hoeijmakers, Wim Vermeulen

Daughter-Specific Transcription Factors Regulate Cell Size Control in Budding Yeast

Stefano Di Talia, Hongyin Wang, Jan M. Skotheim, Adam P. Rosebrock, Bruce Futcher, Frederick R. Cross

Light Directs Zebrafish period2 Expression via Conserved D and E Boxes

Gad Vatine, Daniela Vallone, Lior Appelbaum, Philipp Mracek, Zohar Ben-Moshe, Kajori Lahiri, Yoav Gothilf, Nicholas S. Foulkes

Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors

Dawen Cai, Dyke P. McEwen, Jeffery R. Martens, Edgar Meyhofer, Kristen J. Verhey

Global Conformational Dynamics of a Y-Family DNA Polymerase during Catalysis

Cuiling Xu, Brian A. Maxwell, Jessica A. Brown, Likui Zhang, Zucai Suo

Kissing G Domains of MnmE Monitored by X-Ray Crystallography and Pulse Electron Paramagnetic Resonance Spectroscopy

Simon Meyer, Sabine Böhme, André Krüger, Heinz-Jürgen Steinhoff, Johann P. Klare, Alfred Wittinghofer