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Table of Contents: September 2008

Issue Image

Reticulovesicular network of modified endoplamic reticulum (ER) associated with severe acute respiratory syndrome (SARS)-coronavirus replication. Electron tomography was used to generate a three-dimensional reconstruction of the reticulovesicular network of modified ER induced in Vero E6 cells upon infection with SARS-coronavirus. SARS-coronavirus replication and transcription are associated with this membrane network, which is composed of a large number of conspicuous double membrane vesicles (outer membrane, gold; inner membrane, silver) of which the outer membranes are continuous with convoluted membranes (bronze) and ER cisternae. The surface-rendered model shown here is superimposed on a 1.2-nm-thick tomographic slice. (See Knoops et al., e226)

Synopses

Essay

Book Review/Science in the Media

Primers

Of Mice and Men, and Chandeliers

Alan Woodruff, Rafael Yuste

Community Page

Research Articles

Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex

Gábor Molnár, Szabolcs Oláh, Gergely Komlósi, Miklós Füle, János Szabadics, Csaba Varga, Pál Barzó, Gábor Tamás

L-DOPA Is an Endogenous Ligand for OA1

Vanessa M Lopez, Christina L Decatur, W. Daniel Stamer, Ronald M Lynch, Brian S McKay

Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator

Ji Li, Atsushi Ebata, Yuqing Dong, Gizem Rizki, Terri Iwata, Siu Sylvia Lee

A Morning-Specific Phytohormone Gene Expression Program underlying Rhythmic Plant Growth

Todd P Michael, Ghislain Breton, Samuel P Hazen, Henry Priest, Todd C Mockler, Steve A Kay, Joanne Chory

A Mutual Support Mechanism through Intercellular Movement of CAPRICE and GLABRA3 Can Pattern the Arabidopsis Root Epidermis

Natasha Saint Savage, Tom Walker, Yana Wieckowski, John Schiefelbein, Liam Dolan, Nicholas A. M Monk

Rice XB15, a Protein Phosphatase 2C, Negatively Regulates Cell Death and XA21-Mediated Innate Immunity

Chang-Jin Park, Ying Peng, Xuewei Chen, Christopher Dardick, DeLing Ruan, Rebecca Bart, Patrick E Canlas, Pamela C Ronald

Hrs and SNX3 Functions in Sorting and Membrane Invagination within Multivesicular Bodies

Véronique Pons, Pierre-Philippe Luyet, Etienne Morel, Laurence Abrami, F. Gisou van der Goot, Robert G Parton, Jean Gruenberg

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

Kèvin Knoops, Marjolein Kikkert, Sjoerd H. E. van den Worm, Jessika C Zevenhoven-Dobbe, Yvonne van der Meer, Abraham J Koster, A. Mieke Mommaas, Eric J Snijder

A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila

Jeroen Dobbelaere, Filipe Josué, Saskia Suijkerbuijk, Buzz Baum, Nicolas Tapon, Jordan Raff

Control of Jasmonate Biosynthesis and Senescence by miR319 Targets

Carla Schommer, Javier F Palatnik, Pooja Aggarwal, Aurore Chételat, Pilar Cubas, Edward E Farmer, Utpal Nath, Detlef Weigel

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor

Schoen W Kruse, Kelly Suino-Powell, X. Edward Zhou, Jennifer E Kretschman, Ross Reynolds, Clemens Vonrhein, Yong Xu, Liliang Wang, Sophia Y Tsai, Ming-Jer Tsai, H. Eric Xu

Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation

Joseph M Gonzales, Jigar J Patel, Napawan Ponmee, Lei Jiang, Asako Tan, Steven P Maher, Stefan Wuchty, Pradipsinh K Rathod, Michael T Ferdig

Interconvertible Lac Repressor–DNA Loops Revealed by Single-Molecule Experiments

Oi Kwan Wong, Martin Guthold, Dorothy A Erie, Jeff Gelles

A Specificity Map for the PDZ Domain Family

Raffi Tonikian, Yingnan Zhang, Stephen L Sazinsky, Bridget Currell, Jung-Hua Yeh, Boris Reva, Heike A Held, Brent A Appleton, Marie Evangelista, Yan Wu, Xiaofeng Xin, Andrew C Chan, Somasekar Seshagiri, Laurence A Lasky, Chris Sander, Charles Boone, Gary D Bader, Sachdev S Sidhu

Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis

Young-In Chi, Monika Martick, Monica Lares, Rosalind Kim, William G Scott, Sung-Hou Kim