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Table of Contents: February 2008

COVER

Mcm1 (orange) combines with other transcription factors (blue) to regulate genes.

Image Credit: Image by Brian Tuch and Geraldine Kim
Issue Image

It is widely suspected that gene regulatory networks are highly malleable. To study this plasticity, the evolution of combinatorial gene regulation by Mcm1 and its cofactors was characterized in the yeast lineage (see Tuch et al, e38). In yeast species, Mcm1 (depicted in orange) combines with one of several other transcription factors (depicted in blue) to regulate genes acting in a diverse range of biological processes. Shown here are roughly a hundred of the approximately thousand nucleotide sequences bound by Mcm1 and its cofactors in three yeast species (S. cerevisiae, K. lactis, and C. albicans).

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