Table of Contents: April 2006


104-year-old Helen Reichert (standing, left, aged 9) with her sister and brother.

Image Credit: Photograph provided by Keane family
Issue Image

Helen Reichert is depicted (standing, left) at age nine, with her sister and brother. She is currently 104 years old, and all her siblings achieved exceptional longevity, accompanied by relatively good physical and mental health. Because neither Helen nor her siblings chose particularly healthful lifestyles (Helen has been smoking since age 18), their survival may be attributed to special longevity-assurance genes, according to research reported in this issue of PLoS Biology. See Atzmon et al.


Book Review/Science in the Media

Sour Grapes

William Foster


Community Pages

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

Research Articles

Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

Daniel A Kraut, Paul A Sigala, Brandon Pybus, Corey W Liu, Dagmar Ringe, Gregory A Petsko, Daniel Herschlag

Pathways of Carbon Assimilation and Ammonia Oxidation Suggested by Environmental Genomic Analyses of Marine Crenarchaeota

Steven J Hallam, Tracy J Mincer, Christa Schleper, Christina M Preston, Katie Roberts, Paul M Richardson, Edward F DeLong

Retroposed Elements as Archives for the Evolutionary History of Placental Mammals

Jan Ole Kriegs, Gennady Churakov, Martin Kiefmann, Ursula Jordan, Jürgen Brosius, Jürgen Schmitz

Plasticity of the cis-Regulatory Input Function of a Gene

Avraham E Mayo, Yaakov Setty, Seagull Shavit, Alon Zaslaver, Uri Alon

Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans

Gil Atzmon, Marielisa Rincon, Clyde B Schechter, Alan R Shuldiner, Richard B Lipton, Aviv Bergman, Nir Barzilai

Inefficient Cytotoxic T Lymphocyte–Mediated Killing of HIV-1–Infected Cells In Vivo

Becca Asquith, Charles T. T Edwards, Marc Lipsitch, Angela R McLean

IAN Family Critically Regulates Survival and Development of T Lymphocytes

Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji, Izumi Ohigashi, Tadaaki Miyazaki, Tsutomu Ohta, Masamoto Kanno, Yousuke Takahama

West Nile Virus Epidemics in North America Are Driven by Shifts in Mosquito Feeding Behavior

A. Marm Kilpatrick, Laura D Kramer, Matthew J Jones, Peter P Marra, Peter Daszak

Active Listening for Spatial Orientation in a Complex Auditory Scene

Cynthia F Moss, Kari Bohn, Hannah Gilkenson, Annemarie Surlykke

Training-Induced Plasticity of Auditory Localization in Adult Mammals

Oliver Kacelnik, Fernando R Nodal, Carl H Parsons, Andrew J King

Offline Persistence of Memory-Related Cerebral Activity during Active Wakefulness

Philippe Peigneux, Pierre Orban, Evelyne Balteau, Christian Degueldre, André Luxen, Steven Laureys, Pierre Maquet


Correction: A Map of Recent Positive Selection in the Human Genome

Benjamin F Voight, Sridhar Kudaravalli, Xiaoquan Wen, Jonathan K Pritchard