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Table of Contents: February 2006

COVER

Maria, a female orang-utan (Pongo pygmaeus) from Sabah in Malaysia.

Image Credit: Photo by Jamil Sinyor/KOCP
Issue Image

The photograph depicts Maria, a female orang-utan living in the highly fragmented forest of the Kinabatangan Wildlife Sanctuary in eastern Sabah. Her future is in the hands of humankind, who clearly pushed the species to the brink of extinction during the last century, according to research reported in this issue of PLoS Biology. See Goosens et al.

Editorial

Science in the News

Hemai Parthasarathy

Feature

Unsolved Mystery

Book Review/Science in the Media

Research Articles

Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing

Rebeca Martinez-Contreras, Jean-François Fisette, Faiz-ul Hassan Nasim, Richard Madden, Mélanie Cordeau, Benoit Chabot

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

Orion D Weiner, Maike C Rentel, Alex Ott, Glenn E Brown, Mark Jedrychowski, Michael B Yaffe, Steven P Gygi, Lewis C Cantley, Henry R Bourne, Marc W Kirschner

Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus

Nora G Smart, Åsa A Apelqvist, Xueying Gu, Erin B Harmon, James N Topper, Raymond J MacDonald, Seung K Kim

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente

Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion

Jonathan V Rocheleau, Maria S Remedi, Butch Granada, W. Steven Head, Joseph C Koster, Colin G Nichols, David W Piston

Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo

Richard Benton, Silke Sachse, Stephen W Michnick, Leslie B Vosshall

Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion

Chris B Schaffer, Beth Friedman, Nozomi Nishimura, Lee F Schroeder, Philbert S Tsai, Ford F Ebner, Patrick D Lyden, David Kleinfeld

Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex

Wei-Chung Allen Lee, Hayden Huang, Guoping Feng, Joshua R Sanes, Emery N Brown, Peter T So, Elly Nedivi

Genetic Signature of Anthropogenic Population Collapse in Orang-utans

Benoît Goossens, Lounès Chikhi, Marc Ancrenaz, Isabelle Lackman-Ancrenaz, Patrick Andau, Michael W Bruford