Table of Contents: August 2004


The sites of retorvirus integration overlayed on a schematic of the human genome.

Image Credit: Chromosome image by Huaming Chen, Salk Institute. Design by Jamie Simon, Salk Institute
Issue Image

Sites of retroviral integration are shown arrayed on the human chromosomes. Orange "lollipops" indicate sites of HIV integration; green, MLV; and pink, ASLV. The density of genes on each chromosome is shown by the blue shading. The background shows a high-density microarray such as those used to study the relationship between integration and gene activity. (See Mitchell, et al.)



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Research Articles

Nicotine's Defensive Function in Nature

Anke Steppuhn, Klaus Gase, Bernd Krock, Rayko Halitschke, Ian T Baldwin

Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice

Anne E Bygrave, Kirsten L Rose, Josefina Cortes-Hernandez, Joanna Warren, Robert J Rigby, H. Terence Cook, Mark J Walport, Timothy J Vyse, Marina Botto

Cellular Immune Response to Parasitization in Drosophila Requires the EBF Orthologue Collier

Michèle Crozatier, Jean-Michel Ubeda, Alain Vincent, Marie Meister

Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences

Rick S Mitchell, Brett F Beitzel, Astrid R. W Schroder, Paul Shinn, Huaming Chen, Charles C Berry, Joseph R Ecker, Frederic D Bushman

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H. J Petrini, Titia de Lange

The Regenerative Plasticity of Isolated Urodele Myofibers and Its Dependence on Msx1

Anoop Kumar, Cristiana P Velloso, Yutaka Imokawa, Jeremy P Brockes

A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development

Konstantinos Zarbalis, Scott R May, Yiguo Shen, Marc Ekker, John L. R Rubenstein, Andrew S Peterson

The Zebrafish moonshine Gene Encodes Transcriptional Intermediary Factor 1γ, an Essential Regulator of Hematopoiesis

David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C. Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

IRE1-Independent Gain Control of the Unfolded Protein Response

Jess H Leber, Sebastián Bernales, Peter Walter

Synaptotagmin VII Restricts Fusion Pore Expansion during Lysosomal Exocytosis

Jyoti K Jaiswal, Sabyasachi Chakrabarti, Norma W Andrews, Sanford M Simon

Forgetting, Reminding, and Remembering: The Retrieval of Lost Spatial Memory

Livia de Hoz, Stephen J Martin, Richard G. M Morris