Table of Contents: January 2004


Drosophila testes show their true apoptotic colors.

Image Credit: Cover image provided by Jun R. Huh, California Institute of Technology. Additional photo manipulation by John Heisch, John Heisch Design
Issue Image

Caspases promote apoptotic cell death by cleaving cellular proteins. Multiple caspase cascades are shown to be required for the non-apoptotic process of sperm development. The cover shows images of Drosophila testes labeled with several different antibodies. Coincidentally, when these are viewed as letters they spell "PLoS". (See Huh, et al.)



Science on the Rise in Developing Countries

Milena Holmgren, Stefan A Schnitzer


Book Review/Science in the Media

Journal Club

Channelling Evolution

Jeremy E Niven


Community Page

Research Articles

Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization

Jun R Huh, Stephanie Y Vernooy, Hong Yu, Nieng Yan, Yigong Shi, Ming Guo, Bruce A Hay

Dorsoventral Patterning of the Mouse Coat by Tbx15

Sophie I Candille, Catherine D. Van Raamsdonk, Changyou Chen, Sanne Kuijper, Yanru Chen-Tsai, Andreas Russ, Frits Meijlink, Gregory S Barsh

Contribution of Noncentrosomal Microtubules to Spindle Assembly in Drosophila Spermatocytes

Elena Rebollo, Salud Llamazares, José Reina, Cayetano Gonzalez

HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis

Ajit Janardhan, Tomek Swigut, Brian Hill, Michael P Myers, Jacek Skowronski

Protein Interaction Networks by Proteome Peptide Scanning

Christiane Landgraf, Simona Panni, Luisa Montecchi-Palazzi, Luisa Castagnoli, Jens Schneider-Mergener, Rudolf Volkmer-Engert, Gianni Cesareni

Long-Lasting Novelty-Induced Neuronal Reverberation during Slow-Wave Sleep in Multiple Forebrain Areas

Sidarta Ribeiro, Damien Gervasoni, Ernesto S Soares, Yi Zhou, Shih-Chieh Lin, Janaina Pantoja, Michael Lavine, Miguel A. L Nicolelis

JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome

Xavier I Ambroggio, Douglas C Rees, Raymond J Deshaies