Table of Contents | August 2010

About This Image

Genetic diversity in dog breeds.

The two dog breeds shown demonstrate the high level of diversity seen in dog breeds (see Boyko et al., e 1000451). The larger black dog is an Afghan hound, which is a classic sight hound. The smaller white dog is a Chihuahua mix and is among the smallest of the domestic dog breeds. In addition to body size, the dogs differ in fur length and texture, skull shape, and leg length.

Image Credit: Elaine Ostrander

Synopses

We All Gotta Go Sometime

Robin Meadows

Firing Hot, Firing Cold: How Poikilotherms Compensate for Temperature Swings

Richard Robinson

TRIMming SIV Transmission between Species

Caitlin Sedwick

Protein Aggregation Increases with Age

Rachel Jones

A Dog's Eye View of Morphological Diversity

Liza Gross

Essay

Finding the Right Questions: Exploratory Pathway Analysis to Enhance Biological Discovery in Large Datasets

Thomas Kelder, Bruce R. Conklin, Chris T. Evelo, Alexander R. Pico

Book Review/Science in the Media

Ghost Bird – The Ivory-billed Woodpecker: Hopes, Dreams, and Reality

Jerome A. Jackson

Primer

“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress

Pablo Blanco Martínez de Morentin, Miguel López

Community Page

Incorporating Genomics and Bioinformatics across the Life Sciences Curriculum

Jayna L. Ditty, Christopher A. Kvaal, Brad Goodner, Sharyn K. Freyermuth, Cheryl Bailey, Robert A. Britton, Stuart G. Gordon, Sabine Heinhorst, Kelynne Reed, Zhaohui Xu, Erin R. Sanders-Lorenz, Seth Axen, Edwin Kim, Mitrick Johns, Kathleen Scott, Cheryl A. Kerfeld

Research Articles

Aging in a Long-Lived Clonal Tree

Dilara Ally, Kermit Ritland, Sarah P. Otto

Precise Temperature Compensation of Phase in a Rhythmic Motor Pattern

Lamont S. Tang, Marie L. Goeritz, Jonathan S. Caplan, Adam L. Taylor, Mehmet Fisek, Eve Marder

Motor Preparatory Activity in Posterior Parietal Cortex is Modulated by Subjective Absolute Value

Asha Iyer, Axel Lindner, Igor Kagan, Richard A. Andersen

Auditory Cortex Tracks Both Auditory and Visual Stimulus Dynamics Using Low-Frequency Neuronal Phase Modulation

Huan Luo, Zuxiang Liu, David Poeppel

Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae

Chao Liu, R. Jason Pitts, Jonathan D. Bohbot, Patrick L. Jones, Guirong Wang, Laurence J. Zwiebel

The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis and Prevents Learning Impairments Following Sleep Loss

Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

Eduardo R. Ropelle, Marcelo B. Flores, Dennys E. Cintra, Guilherme Z. Rocha, José R. Pauli, Joseane Morari, Claudio T. de Souza, Juliana C. Moraes, Patrícia O. Prada, Dioze Guadagnini, Rodrigo M. Marin, Alexandre G. Oliveira, Taize M. Augusto, Hernandes F. Carvalho, Lício A. Velloso, Mario J. A. Saad, José B. C. Carvalheira

A Short Receptor Downregulates JAK/STAT Signalling to Control the Drosophila Cellular Immune Response

Rami Makki, Marie Meister, Delphine Pennetier, Jean-Michel Ubeda, Anne Braun, Virginie Daburon, Joanna Krzemień, Henri-Marc Bourbon, Rui Zhou, Alain Vincent, Michèle Crozatier

TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species

Andrea Kirmaier, Fan Wu, Ruchi M. Newman, Laura R. Hall, Jennifer S. Morgan, Shelby O'Connor, Preston A. Marx, Mareike Meythaler, Simoy Goldstein, Alicia Buckler-White, Amitinder Kaur, Vanessa M. Hirsch, Welkin E. Johnson

Rac1-Dependent Collective Cell Migration Is Required for Specification of the Anterior-Posterior Body Axis of the Mouse

Isabelle Migeotte, Tatiana Omelchenko, Alan Hall, Kathryn V. Anderson

A Complete Developmental Sequence of a Drosophila Neuronal Lineage as Revealed by Twin-Spot MARCM

Hung-Hsiang Yu, Chih-Fei Kao, Yisheng He, Peng Ding, Jui-Chun Kao, Tzumin Lee

Foxp1 and Lhx1 Coordinate Motor Neuron Migration with Axon Trajectory Choice by Gating Reelin Signalling

Elena Palmesino, David L. Rousso, Tzu-Jen Kao, Avihu Klar, Ed Laufer, Osamu Uemura, Hitoshi Okamoto, Bennett G. Novitch, Artur Kania

Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

Alfonso Lavado, Oleg V. Lagutin, Lionel M. L. Chow, Suzanne J. Baker, Guillermo Oliver

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

Tracy M. Yamawaki, Jennifer R. Berman, Monika Suchanek-Kavipurapu, Mark McCormick, Marta Maria Gaglia, Seung-Jae Lee, Cynthia Kenyon

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

Della C. David, Noah Ollikainen, Jonathan C. Trinidad, Michael P. Cary, Alma L. Burlingame, Cynthia Kenyon

A Simple Genetic Architecture Underlies Morphological Variation in Dogs

Adam R. Boyko, Pascale Quignon, Lin Li, Jeffrey J. Schoenebeck, Jeremiah D. Degenhardt, Kirk E. Lohmueller, Keyan Zhao, Abra Brisbin, Heidi G. Parker, Bridgett M. vonHoldt, Michele Cargill, Adam Auton, Andy Reynolds, Abdel G. Elkahloun, Marta Castelhano, Dana S. Mosher, Nathan B. Sutter, Gary S. Johnson, John Novembre, Melissa J. Hubisz, Adam Siepel, Robert K. Wayne, Carlos D. Bustamante, Elaine A. Ostrander