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Table of Contents: July 2015

COVER

Energy Shortfall Causes Blindness

Image Credit: Manish Jaiswal
Issue Image

Some mitochondrial disorders cause blindness through increased oxidative stress. A new study by Manish Jaiswal, Hugo Bellen and co-authors shows that in other such disorders, light-activated photoreceptors degenerate because the shortfall in mitochondrial energy production impairs rhodopsin trafficking and induces toxicity. This image shows photoreceptor neurons of the fruit fly Drosophila melanogaster, with the photoreceptors visualized by phalloidin (green). The light-sensitive protein rhodopsin 1 (yellow) is aberrantly localized in the cytoplasm of those photoreceptors that have defective mitochondria (non-blue), while the normal photoreceptors are marked by RFP (blue). Jaiswal et al.

Essays

Perspectives

Big Data: Astronomical or Genomical?

Zachary D. Stephens, Skylar Y. Lee, Faraz Faghri, Roy H. Campbell, Chengxiang Zhai, Miles J. Efron, Ravishankar Iyer, Michael C. Schatz, Saurabh Sinha, Gene E. Robinson

Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording

Luke Holman, Megan L. Head, Robert Lanfear, Michael D. Jennions

Where Next for Genetics and Genomics?

Chris Tyler-Smith, Huanming Yang, Laura F. Landweber, Ian Dunham, Bartha M. Knoppers, Peter Donnelly, Elaine R. Mardis, Michael Snyder, Gil McVean

Community Page

The Importance of Biodiversity E-infrastructures for Megadiverse Countries

Dora A. L. Canhos, Mariane S. Sousa-Baena, Sidnei de Souza, Leonor C. Maia, João R. Stehmann, Vanderlei P. Canhos, Renato De Giovanni, Maria B. M. Bonacelli, Wouter Los, A. Townsend Peterson

Research Articles

Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

Andrew F. Read, Susan J. Baigent, Claire Powers, Lydia B. Kgosana, Luke Blackwell, Lorraine P. Smith, David A. Kennedy, Stephen W. Walkden-Brown, Venugopal K. Nair

Biofilm Formation As a Response to Ecological Competition

Nuno M. Oliveira, Esteban Martinez-Garcia, Joao Xavier, William M. Durham, Roberto Kolter, Wook Kim, Kevin R. Foster

Auditory Processing in Noise: A Preschool Biomarker for Literacy

Travis White-Schwoch, Kali Woodruff Carr, Elaine C. Thompson, Samira Anderson, Trent Nicol, Ann R. Bradlow, Steven G. Zecker, Nina Kraus

The Functional Connectome of Speech Control

Stefan Fuertinger, Barry Horwitz, Kristina Simonyan

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

Xavier Viñals, Estefanía Moreno, Laurence Lanfumey, Arnau Cordomí, Antoni Pastor, Rafael de La Torre, Paola Gasperini, Gemma Navarro, Lesley A. Howell, Leonardo Pardo, Carmen Lluís, Enric I. Canela, Peter J. McCormick, Rafael Maldonado, Patricia Robledo

Glypican Is a Modulator of Netrin-Mediated Axon Guidance

Cassandra R. Blanchette, Paola N. Perrat, Andrea Thackeray, Claire Y. Bénard

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D’Acquisto, Elliot J. Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M. Marelli-Berg, Claudio Mauro

The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster

Claire L. Webster, Fergal M. Waldron, Shaun Robertson, Daisy Crowson, Giada Ferrari, Juan F. Quintana, Jean-Michel Brouqui, Elizabeth H. Bayne, Ben Longdon, Amy H. Buck, Brian P. Lazzaro, Jewelna Akorli, Penelope R. Haddrill, Darren J. Obbard

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress

Manish Jaiswal, Nele A. Haelterman, Hector Sandoval, Bo Xiong, Taraka Donti, Auinash Kalsotra, Shinya Yamamoto, Thomas A. Cooper, Brett H. Graham, Hugo J. Bellen

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila

Xiao-Jun Xie, Fu-Ning Hsu, Xinsheng Gao, Wu Xu, Jian-Quan Ni, Yue Xing, Liying Huang, Hao-Ching Hsiao, Haiyan Zheng, Chenguang Wang, Yani Zheng, Alus M. Xiaoli, Fajun Yang, Sarah E. Bondos, Jun-Yuan Ji

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii

Daniel P. Beiting, Shinya Hidano, Julie E. Baggs, Jeanne M. Geskes, Qun Fang, E. John Wherry, Christopher A. Hunter, David S. Roos, Sara Cherry

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme

Ping Zhang, Matthias J. Knape, Lalima G. Ahuja, Malik M. Keshwani, Charles C. King, Mira Sastri, Friedrich W. Herberg, Susan S. Taylor