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Table of Contents: October 2014

Issue Image

The driver CHA-Gal4 is used to simultaneously express GFP and a nuclear RFP in cholinergic neurons. In cells with short processes, both GFP and RFP expression are more tightly localized in the nucleus, resulting in cells with yellow nuclei. In contrast, in cells with long processes, GFP spreads out resulting in nuclei with relatively stronger red fluorescence. On top of this, nuclear localization of DATI transcription factor is labeled in blue. This color-code allows the detection of four distinct classes of neurons: DATI- CHA+ neurons appear in green; DATI+ CHA- neurons in blue; DATI+ CHA+ neurons with short processes in light blue, and DATI+CHA+ neurons with long processes in magenta. Processes of CHA+ neurons appear in green. See Schinaman et al.

Synopses

Essays

From “Silent Teachers” to Models

Roos Eisma, Tracey Wilkinson

Perspectives

Primer

Research Articles

Adaptive Management and the Value of Information: Learning Via Intervention in Epidemiology

Katriona Shea, Michael J. Tildesley, Michael C. Runge, Christopher J. Fonnesbeck, Matthew J. Ferrari

Occipital Alpha Activity during Stimulus Processing Gates the Information Flow to Object-Selective Cortex

Johanna M. Zumer, René Scheeringa, Jan-Mathijs Schoffelen, David G. Norris, Ole Jensen

A Synaptic Mechanism for Temporal Filtering of Visual Signals

Tom Baden, Anton Nikolaev, Federico Esposti, Elena Dreosti, Benjamin Odermatt, Leon Lagnado

A Homeostatic Sleep-Stabilizing Pathway in Drosophila Composed of the Sex Peptide Receptor and Its Ligand, the Myoinhibitory Peptide

Yangkyun Oh, Sung-Eun Yoon, Qi Zhang, Hyo-Seok Chae, Ivana Daubnerová, Orie T. Shafer, Joonho Choe, Young-Joon Kim

The KRÜPPEL-Like Transcription Factor DATILÓGRAFO Is Required in Specific Cholinergic Neurons for Sexual Receptivity in Drosophila Females

Joseph Moeller Schinaman, Rachel Lynn Giesey, Claudia Mieko Mizutani, Tamas Lukacsovich, Rui Sousa-Neves

Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal

Andrew J. Muinonen-Martin, Olivia Susanto, Qifeng Zhang, Elizabeth Smethurst, William J. Faller, Douwe M. Veltman, Gabriela Kalna, Colin Lindsay, Dorothy C. Bennett, Owen J. Sansom, Robert Herd, Robert Jones, Laura M. Machesky, Michael J. O. Wakelam, David A. Knecht, Robert H. Insall

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

Sujoy Lahiri, Jesse T. Chao, Shabnam Tavassoli, Andrew K. O. Wong, Vineet Choudhary, Barry P. Young, Christopher J. R. Loewen, William A. Prinz

Centromere-Independent Accumulation of Cohesin at Ectopic Heterochromatin Sites Induces Chromosome Stretching during Anaphase

Raquel A. Oliveira, Shaila Kotadia, Alexandra Tavares, Mihailo Mirkovic, Katherine Bowlin, Christian S. Eichinger, Kim Nasmyth, William Sullivan

A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus

Joshua W. Modell, Tracy K. Kambara, Barrett S. Perchuk, Michael T. Laub

The Chromatin Assembly Factor 1 Promotes Rad51-Dependent Template Switches at Replication Forks by Counteracting D-Loop Disassembly by the RecQ-Type Helicase Rqh1

Violena Pietrobon, Karine Fréon, Julien Hardy, Audrey Costes, Ismail Iraqui, Françoise Ochsenbein, Sarah A.E. Lambert

DEAD-Box Helicase Proteins Disrupt RNA Tertiary Structure Through Helix Capture

Cynthia Pan, Jeffrey P. Potratz, Brian Cannon, Zachary B. Simpson, Jessica L. Ziehr, Pilar Tijerina, Rick Russell

Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase

W. Seth Childers, Qingping Xu, Thomas H. Mann, Irimpan I. Mathews, Jimmy A. Blair, Ashley M. Deacon, Lucy Shapiro