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Table of Contents: March 2014

COVER

Blowfly Thorax.

Image Credit: Simon M Walker, University of Oxford
Issue Image

Cutaway three-dimensional visualization of a blowfly thorax created using in-vivo time-resolved microtomography. Several of the tiny steering muscles are highlighted (green to blue) alongside the much larger power muscles (yellow to red). View the full video here. See Taylor et al.

Synopses

Essay

Unsolved Mystery

Perspectives

Making De-Extinction Mundane?

Carrie Friese, Claire Marris

Close the High Seas to Fishing?

Crow White, Christopher Costello

Primer

Research Articles

In Vivo Time-Resolved Microtomography Reveals the Mechanics of the Blowfly Flight Motor

Simon M. Walker, Daniel A. Schwyn, Rajmund Mokso, Martina Wicklein, Tonya Müller, Michael Doube, Marco Stampanoni, Holger G. Krapp, Graham K. Taylor

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

Mathieu Brochet, Mark O. Collins, Terry K. Smith, Eloise Thompson, Sarah Sebastian, Katrin Volkmann, Frank Schwach, Lia Chappell, Ana Rita Gomes, Matthew Berriman, Julian C. Rayner, David A. Baker, Jyoti Choudhary, Oliver Billker

Brain Endothelial Cells Control Fertility through Ovarian-Steroid–Dependent Release of Semaphorin 3A

Paolo Giacobini, Jyoti Parkash, Céline Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Barbara Hobo, Gabriella Cagnoni, Sarah Gallet, Naresh Kumar Hanchate, Danièle Mazur, Masahiko Taniguchi, Massimiliano Mazzone, Joost Verhaagen, Philippe Ciofi, Sébastien G. Bouret, Luca Tamagnone, Vincent Prevot

Dual PDF Signaling Pathways Reset Clocks Via TIMELESS and Acutely Excite Target Neurons to Control Circadian Behavior

Adam Seluzicki, Matthieu Flourakis, Elzbieta Kula-Eversole, Luoying Zhang, Valerie Kilman, Ravi Allada

Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling

Rajesh Jayachandran, Xiaolong Liu, Somdeb BoseDasgupta, Philipp Müller, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A. Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi, Yann Humeau, Jean Pieters

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

Benjamin D. Harrison, Jordan Hashemi, Maayan Bibi, Rebecca Pulver, Danny Bavli, Yaakov Nahmias, Melanie Wellington, Guillermo Sapiro, Judith Berman

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

Dariel Ashton-Beaucage, Christian M. Udell, Patrick Gendron, Malha Sahmi, Martin Lefrançois, Caroline Baril, Anne-Sophie Guenier, Jean Duchaine, Daniel Lamarre, Sébastien Lemieux, Marc Therrien

JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation

Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun, Yongfeng Shang

RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage

Zubaidah M. Ramdzan, Charles Vadnais, Ranjana Pal, Guillaume Vandal, Chantal Cadieux, Lam Leduy, Sayeh Davoudi, Laura Hulea, Lu Yao, Anthony N. Karnezis, Marilène Paquet, David Dankort, Alain Nepveu

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

Diego M. Presman, M. Florencia Ogara, Martín Stortz, Lautaro D. Alvarez, John R. Pooley, R. Louis Schiltz, Lars Grøntved, Thomas A. Johnson, Paul R. Mittelstadt, Jonathan D. Ashwell, Sundar Ganesan, Gerardo Burton, Valeria Levi, Gordon L. Hager, Adali Pecci