Table of Contents: January 2014


Structure and mechanism of baculovirus actin tails.

Image Credit: IMBA graphics
Issue Image

A cunning group of pathogens induce comet tails of actin in host cytoplasm to spread their infection from one cell to the next. Mueller et al. use electron tomography to elucidate the structure of and insect virus actin comets and provide new insights into the mechanism of actin-based pathogen propulsion.


Open Science and Reporting Animal Studies: Who's Accountable?

Jonathan A. Eisen, Emma Ganley, Catriona J. MacCallum




Troubleshooting Public Data Archiving: Suggestions to Increase Participation

Dominique G. Roche, Robert Lanfear, Sandra A. Binning, Tonya M. Haff, Lisa E. Schwanz, Kristal E. Cain, Hanna Kokko, Michael D. Jennions, Loeske E. B. Kruuk

Revising the Economic Imperative for US STEM Education

Brian M. Donovan, David Moreno Mateos, Jonathan F. Osborne, Daniel J. Bisaccio


Community Pages

Best Practices for Scientific Computing

Greg Wilson, D. A. Aruliah, C. Titus Brown, Neil P. Chue Hong, Matt Davis, Richard T. Guy, Steven H. D. Haddock, Kathryn D. Huff, Ian M. Mitchell, Mark D. Plumbley, Ben Waugh, Ethan P. White, Paul Wilson

A Field Guide to Genomics Research

Andrea H. Bild, Jeffrey T. Chang, W. Evan Johnson, Stephen R. Piccolo

Overcoming the Barriers to Greater Public Engagement

Ian M. Devonshire, Gareth J. Hathway

Research Articles

Different Levels of Catabolite Repression Optimize Growth in Stable and Variable Environments

Aaron M. New, Bram Cerulus, Sander K. Govers, Gemma Perez-Samper, Bo Zhu, Sarah Boogmans, Joao B. Xavier, Kevin J. Verstrepen

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Joost M. Woltering, Daan Noordermeer, Marion Leleu, Denis Duboule

Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11

Wu-Lin Charng, Shinya Yamamoto, Manish Jaiswal, Vafa Bayat, Bo Xiong, Ke Zhang, Hector Sandoval, Gabriela David, Stephen Gibbs, Hsiang-Chih Lu, Kuchuan Chen, Nikos Giagtzoglou, Hugo J. Bellen

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

Ulyana Lalo, Oleg Palygin, Seyed Rasooli-Nejad, Jemma Andrew, Philip G. Haydon, Yuriy Pankratov

The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity

Anissa Kempf, Bjoern Tews, Michael E. Arzt, Oliver Weinmann, Franz J. Obermair, Vincent Pernet, Marta Zagrebelsky, Andrea Delekate, Cristina Iobbi, Ajmal Zemmar, Zorica Ristic, Miriam Gullo, Peter Spies, Dana Dodd, Daniel Gygax, Martin Korte, Martin E. Schwab

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

Klaus Heger, Kaat Fierens, J. Christoph Vahl, Attila Aszodi, Katrin Peschke, Dominik Schenten, Hamida Hammad, Rudi Beyaert, Dieter Saur, Geert van Loo, Axel Roers, Bart N. Lambrecht, Mirjam Kool, Marc Schmidt-Supprian

Mycobacterium tuberculosis Ser/Thr Protein Kinase B Mediates an Oxygen-Dependent Replication Switch

Corrie Ortega, Reiling Liao, Lindsey N. Anderson, Tige Rustad, Anja R. Ollodart, Aaron T. Wright, David R. Sherman, Christoph Grundner

Electron Tomography and Simulation of Baculovirus Actin Comet Tails Support a Tethered Filament Model of Pathogen Propulsion

Jan Mueller, Julia Pfanzelter, Christoph Winkler, Akihiro Narita, Christophe Le Clainche, Maria Nemethova, Marie-France Carlier, Yuichiro Maeda, Matthew D. Welch, Taro Ohkawa, Christian Schmeiser, Guenter P. Resch, J. Victor Small

Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation

Ariel E. Mechaly, Nathalie Sassoon, Jean-Michel Betton, Pedro M. Alzari