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Table of Contents: September 2013

COVER

Molecular switch behind programmed cell death of the plant embryo suspensor

Image Credit: Peng Zhao and Meng-xiang Sun
Issue Image

A molecular mechanism involving a protease inhibitor, cystatin NtCYS, and its target, the protease NtCP14, regulate the programmed cell death of the suspensor organ during plant embryogenesis. See Zhao et al. (e1001655) in this issue.

Synopses

Perspectives

Spatially Explicit Data: Stewardship and Ethical Challenges in Science

Joel Hartter, Sadie J. Ryan, Catrina A. MacKenzie, John N. Parker, Carly A. Strasser

Lost Branches on the Tree of Life

Bryan T. Drew, Romina Gazis, Patricia Cabezas, Kristen S. Swithers, Jiabin Deng, Roseana Rodriguez, Laura A. Katz, Keith A. Crandall, David S. Hibbett, Douglas E. Soltis

Obituary

Research Articles

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

Christopher S. Carlson, Tara C. Matise, Kari E. North, Christopher A. Haiman, Megan D. Fesinmeyer, Steven Buyske, Fredrick R. Schumacher, Ulrike Peters, Nora Franceschini, Marylyn D. Ritchie, David J. Duggan, Kylee L. Spencer, Logan Dumitrescu, Charles B. Eaton, Fridtjof Thomas, Alicia Young, Cara Carty, Gerardo Heiss, Loic Le Marchand, Dana C. Crawford, Lucia A. Hindorff, Charles L. Kooperberg , for the PAGE Consortium

Unisexual and Heterosexual Meiotic Reproduction Generate Aneuploidy and Phenotypic Diversity De Novo in the Yeast Cryptococcus neoformans

Min Ni, Marianna Feretzaki, Wenjun Li, Anna Floyd-Averette, Piotr Mieczkowski, Fred S. Dietrich, Joseph Heitman

Brain Systems for Probabilistic and Dynamic Prediction: Computational Specificity and Integration

Jill X. O'Reilly, Saad Jbabdi, Matthew F. S. Rushworth, Timothy E. J. Behrens

A Cullin1-Based SCF E3 Ubiquitin Ligase Targets the InR/PI3K/TOR Pathway to Regulate Neuronal Pruning

Jack Jing Lin Wong, Song Li, Edwin Kok Hao Lim, Yan Wang, Cheng Wang, Heng Zhang, Daniel Kirilly, Chunlai Wu, Yih-Cherng Liou, Hongyan Wang, Fengwei Yu

A Bipartite Molecular Module Controls Cell Death Activation in the Basal Cell Lineage of Plant Embryos

Peng Zhao, Xue-mei Zhou, Li-yao Zhang, Wei Wang, Li-gang Ma, Li-bo Yang, Xiong-bo Peng, Peter V. Bozhkov, Meng-xiang Sun

Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism

Ross A. Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J. Ragan, James A. West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C. Kienesberger, Ryszard T. Smolenski, Hillary K. Siddall, John L. Offer, Mihaela M. Mocanu, Derek M. Yelon, Jason R. B. Dyck, Jules L. Griffin, Andrey Y. Abramov, Alex P. Gould, Timothy J. Mohun

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

Tobias Eckle, Kelley Brodsky, Megan Bonney, Thomas Packard, Jun Han, Christoph H. Borchers, Thomas J. Mariani, Douglas J. Kominsky, Michel Mittelbronn, Holger K. Eltzschig

Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells

Nicolas Rochereau, Daniel Drocourt, Eric Perouzel, Vincent Pavot, Pierre Redelinghuys, Gordon D. Brown, Gerard Tiraby, Xavier Roblin, Bernard Verrier, Christian Genin, Blaise Corthésy, Stéphane Paul

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

Thomas L. Rodgers, Philip D. Townsend, David Burnell, Matthew L. Jones, Shane A. Richards, Tom C. B. McLeish, Ehmke Pohl, Mark R. Wilson, Martin J. Cann

Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

Kaheina Aizel, Valérie Biou, Jorge Navaza, Lionel V. Duarte, Valérie Campanacci, Jacqueline Cherfils, Mahel Zeghouf

Mechanism of Membranous Tunnelling Nanotube Formation in Viral Genome Delivery

Bibiana Peralta, David Gil-Carton, Daniel Castaño-Díez, Aurelie Bertin, Claire Boulogne, Hanna M. Oksanen, Dennis H. Bamford, Nicola G. A. Abrescia

Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-κB-Driven Transcription

Sulakshana P. Mukherjee, Marcelo Behar, Harry A. Birnbaum, Alexander Hoffmann, Peter E. Wright, Gourisankar Ghosh