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Table of Contents: December 2012

COVER

A striated fiber is required for daughter cell budding in Toxoplasma gondii.

Image Credit: Maria Francia & Boris Striepen, University of Georgia.
Issue Image

This immunofluorescence image shows humans fibroblasts infected with a mutant of the intracellular parasite Toxoplasma gondii. This mutant fails to express the striated fiber protein TgSFA3, and as a consequence does not initiate daughter cell formation during mitosis. Note that in this mutant, parasite cells contain two nuclei. Nuclei are shown in blue, and the outline of the parasites is shown in green with a red apical cap (pellicle components IMC1 and ISP1, respectively). See Francia et al. (e1001444) in this issue.

Synopses

Primer

Community Pages

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Hina Kalra, Richard J. Simpson, Hong Ji, Elena Aikawa, Peter Altevogt, Philip Askenase, Vincent C. Bond, Francesc E. Borràs, Xandra Breakefield, Vivian Budnik, Edit Buzas, Giovanni Camussi, Aled Clayton, Emanuele Cocucci, Juan M. Falcon-Perez, Susanne Gabrielsson, Yong Song Gho, Dwijendra Gupta, H. C. Harsha, An Hendrix, Andrew F. Hill, Jameel M. Inal, Guido Jenster, Eva-Maria Krämer-Albers, Sai Kiang Lim, Alicia Llorente, Jan Lötvall, Antonio Marcilla, Lucia Mincheva-Nilsson, Irina Nazarenko, Rienk Nieuwland, Esther N. M. Nolte-'t Hoen, Akhilesh Pandey, Tushar Patel, Melissa G. Piper, Stefano Pluchino, T. S. Keshava Prasad, Lawrence Rajendran, Graca Raposo, Michel Record, Gavin E. Reid, Francisco Sánchez-Madrid, Raymond M. Schiffelers, Pia Siljander, Allan Stensballe, Willem Stoorvogel, Douglas Taylor, Clotilde Thery, Hadi Valadi, Bas W. M. van Balkom, Jesús Vázquez, Michel Vidal, Marca H. M. Wauben, María Yáñez-Mó, Margot Zoeller, Suresh Mathivanan

The Human Brain Online: An Open Resource for Advancing Brain Research

Sara Ball, Terri L. Gilbert, Caroline C. Overly

Research Articles

Disease Ecology, Biodiversity, and the Latitudinal Gradient in Income

Matthew H. Bonds, Andrew P. Dobson, Donald C. Keenan

Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

Karin Voordeckers, Chris A. Brown, Kevin Vanneste, Elisa van der Zande, Arnout Voet, Steven Maere, Kevin J. Verstrepen

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

Nuria Izquierdo-Useros, Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger, Elina Erikson, Maria Pino, Itziar Erkizia, Bärbel Glass, Bonaventura Clotet, Oliver T. Keppler, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

Maria Kalyuga, David Gallego-Ortega, Heather J. Lee, Daniel L. Roden, Mark J. Cowley, C. Elizabeth Caldon, Andrew Stone, Stephanie L. Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L. Statham, Nicola Armstrong, M. Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L. Piggin, Cara J. Evans, Anita Ledger, Tilman Brummer, Samantha R. Oakes, Warren Kaplan, Julia M. W. Gee, Robert I. Nicholson, Robert L. Sutherland, Alexander Swarbrick, Matthew J. Naylor, Susan J. Clark, Jason S. Carroll, Christopher J. Ormandy

Growth Cone MKK7 mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

Daniel Feltrin, Ludovico Fusco, Harald Witte, Francesca Moretti, Katrin Martin, Michel Letzelter, Erika Fluri, Peter Scheiffele, Olivier Pertz

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Xin Xiong, Yan Hao, Kan Sun, Jiaxing Li, Xia Li, Bibhudatta Mishra, Pushpanjali Soppina, Chunlai Wu, Richard I. Hume, Catherine A. Collins

Cell Division in Apicomplexan Parasites Is Organized by a Homolog of the Striated Rootlet Fiber of Algal Flagella

Maria E. Francia, Carly N. Jordan, Jay D. Patel, Lilach Sheiner, Jessica L. Demerly, Justin D. Fellows, Jessica Cruz de Leon, Naomi S. Morrissette, Jean-François Dubremetz, Boris Striepen

Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm

Nitika Raychaudhuri, Raphaelle Dubruille, Guillermo A. Orsi, Homayoun C. Bagheri, Benjamin Loppin, Christian F. Lehner

The Cell Cycle Timing of Centromeric Chromatin Assembly in Drosophila Meiosis Is Distinct from Mitosis Yet Requires CAL1 and CENP-C

Elaine M. Dunleavy, Nicole L. Beier, Walter Gorgescu, Jonathan Tang, Sylvain V. Costes, Gary H. Karpen

Crag Is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells

Bo Xiong, Vafa Bayat, Manish Jaiswal, Ke Zhang, Hector Sandoval, Wu-Lin Charng, Tongchao Li, Gabriela David, Lita Duraine, Yong-Qi Lin, G. Gregory Neely, Shinya Yamamoto, Hugo J. Bellen

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

Carolin Seuring, Jason Greenwald, Christian Wasmer, Roger Wepf, Sven J. Saupe, Beat H. Meier, Roland Riek

Intracellular Proton Access in a Cl/H+ Antiporter

Hyun-Ho Lim, Tania Shane, Christopher Miller

Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

Mioara Larion, Roberto Kopke Salinas, Lei Bruschweiler-Li, Brian G. Miller, Rafael Brüschweiler