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Table of Contents: April 2013

COVER

Escape response of the nematode Caenorhabditis elegans

Image Credit: Jeremy T. Florman, Christopher M. Clark, and Mark J. Alkema
Issue Image

Complex behaviors require the temporal coordination of distinct motor programs. The escape response of the nematode C. elegans consists of a compound motor sequence in which the animal coordinates head and body movements to reverse direction and turn away from a noxious stimulus. These studies show how a monoamine neurotransmitter orchestrates different phases of the escape response through the synaptic activation of a fast-acting ion channel and extrasynaptic activation of a slow-acting G-protein coupled receptor. See Donnelly et al. in this issue.

Synopses

Unsolved Mystery

The Case of the Missing Mechanism: How Does Temperature Influence Seasonal Timing in Endotherms?

Samuel P. Caro, Sonja V. Schaper, Roelof A. Hut, Gregory F. Ball, Marcel E. Visser

Perspectives

Subgrouping the Autism “Spectrum": Reflections on DSM-5

Meng-Chuan Lai, Michael V. Lombardo, Bhismadev Chakrabarti, Simon Baron-Cohen

An Introduction to Social Media for Scientists

Holly M. Bik, Miriam C. Goldstein

Primer

Cooperation and the Fate of Microbial Societies

Benjamin Allen, Martin A. Nowak

Community Page

COMPASS: Navigating the Rules of Scientific Engagement

Brooke Smith, Nancy Baron, Chad English, Heather Galindo, Erica Goldman, Karen McLeod, Meghan Miner, Elizabeth Neeley

Research Articles

When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition

Rafael Pena-Miller, David Laehnemann, Gunther Jansen, Ayari Fuentes-Hernandez, Philip Rosenstiel, Hinrich Schulenburg, Robert Beardmore

A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta

Jinhua Lu, Shuang Zhang, Haruo Nakano, David G. Simmons, Shumin Wang, Shuangbo Kong, Qiang Wang, Lianju Shen, Zhaowei Tu, Weixiang Wang, Bingyan Wang, Hongmei Wang, Yanling Wang, Johan H. van Es, Hans Clevers, Gustavo Leone, James C. Cross, Haibin Wang

Vascular Calcifying Progenitor Cells Possess Bidirectional Differentiation Potentials

Hyun-Ju Cho, Hyun-Jai Cho, Ho-Jae Lee, Myung-Kang Song, Ji-Yun Seo, Yeon-Hee Bae, Ju-Young Kim, Hae-Young Lee, Whal Lee, Bon-Kwon Koo, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim

JAGGED Controls Arabidopsis Petal Growth and Shape by Interacting with a Divergent Polarity Field

Susanna Sauret-Güeto, Katharina Schiessl, Andrew Bangham, Robert Sablowski, Enrico Coen

Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior

Jamie L. Donnelly, Christopher M. Clark, Andrew M. Leifer, Jennifer K. Pirri, Marian Haburcak, Michael M. Francis, Aravinthan D. T. Samuel, Mark J. Alkema

Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

Ryo Suzuki, Heather A. Ferris, Melissa J. Chee, Eleftheria Maratos-Flier, C. Ronald Kahn

Transsynaptic Coordination of Synaptic Growth, Function, and Stability by the L1-Type CAM Neuroglian

Eva-Maria Enneking, Sirisha R. Kudumala, Eliza Moreno, Raiko Stephan, Jana Boerner, Tanja A. Godenschwege, Jan Pielage

Ligands for Pheromone-Sensing Neurons Are Not Conformationally Activated Odorant Binding Proteins

Carolina Gomez-Diaz, Jaime H. Reina, Christian Cambillau, Richard Benton

Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension

Claire E. Kelly, Efstathia Thymiakou, James E. Dixon, Shinya Tanaka, Jonathan Godwin, Vasso Episkopou

Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1

Rafael Sanjuán, Miguel R. Nebot, Joan B. Peris, José Alcamí

Synthesis of Very-Long-Chain Fatty Acids in the Epidermis Controls Plant Organ Growth by Restricting Cell Proliferation

Takashi Nobusawa, Yoko Okushima, Noriko Nagata, Mikiko Kojima, Hitoshi Sakakibara, Masaaki Umeda

RanBP2/Nup358 Potentiates the Translation of a Subset of mRNAs Encoding Secretory Proteins

Kohila Mahadevan, Hui Zhang, Abdalla Akef, Xianying A. Cui, Serge Gueroussov, Can Cenik, Frederick P. Roth, Alexander F. Palazzo

Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGF-β–TAK1–Dependent Mechanism

Yulei Shang, Christina N. Doan, Thomas D. Arnold, Sebum Lee, Amy A. Tang, Louis F. Reichardt, Eric J. Huang

Promoter Sequence Determines the Relationship between Expression Level and Noise

Lucas B. Carey, David van Dijk, Peter M. A. Sloot, Jaap A. Kaandorp, Eran Segal

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Kenneth K. Y. Cheng, Aimin Xu, Kwong-Man Lee, Liwen Jiang, Jun Xia

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance

Birgitte Holst, Kenneth L. Madsen, Anna M. Jansen, Chunyu Jin, Mattias Rickhag, Viktor K. Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N. Madsen, Zhichao Xue, Siri K. Møller, David Woldbye, Klaus Qvortrup, Richard Huganir, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether

Directional Transport Is Mediated by a Dynein-Dependent Step in an RNA Localization Pathway

James A. Gagnon, Jill A. Kreiling, Erin A. Powrie, Timothy R. Wood, Kimberly L. Mowry