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Table of Contents: February 2013

COVER

Molecular basis of FK506 inhibition of calcineurin.

Image Credit: Simina Grigoriu
Issue Image

Calcineurin (gray, catalytic A-subunit; beige, structural B-subunit) is the target of the most widely used immunosuppressant drug, FK506 (ball-and-stick model). FK506 and the viral inhibitor A238L (purple) share a common calcineurin substrate binding site, the LxVP site, which is located at the intersection of the two calcineurin subunits. The structure of the calcineurin:A238L complex led to an in-depth understanding of substrate binding and dephosphorylation by calcineurin. See Grigoriu, et al. (e1001492) in this issue.

Synopses

Perspective

Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials

Beverly S. Muhlhausler, Frank H. Bloomfield, Matthew W. Gillman

Book Review/Science in the Media

Primers

Hitchhiking to Speciation

Daven C. Presgraves

Community Page

Integrating Art and Science in Undergraduate Education

Daniel Gurnon, Julian Voss-Andreae, Jacob Stanley

Research Articles

Indirect Evolution of Hybrid Lethality Due to Linkage with Selected Locus in Mimulus guttatus

Kevin M. Wright, Deborah Lloyd, David B. Lowry, Mark R. Macnair, John H. Willis

The Bilaterian Head Patterning Gene six3/6 Controls Aboral Domain Development in a Cnidarian

Chiara Sinigaglia, Henriette Busengdal, Lucas Leclère, Ulrich Technau, Fabian Rentzsch

Strength of Gamma Rhythm Depends on Normalization

Supratim Ray, Amy M. Ni, John H. R. Maunsell

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

Cong Cao, Mengia S. Rioult-Pedotti, Paolo Migani, Crystal J. Yu, Rakesh Tiwari, Keykavous Parang, Mark R. Spaller, Dennis J. Goebel, John Marshall

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

Amandine Girousse, Geneviève Tavernier, Carine Valle, Cedric Moro, Niklas Mejhert, Anne-Laure Dinel, Marianne Houssier, Balbine Roussel, Aurèle Besse-Patin, Marion Combes, Lucile Mir, Laurent Monbrun, Véronic Bézaire, Bénédicte Prunet-Marcassus, Aurélie Waget, Isabelle Vila, Sylvie Caspar-Bauguil, Katie Louche, Marie-Adeline Marques, Aline Mairal, Marie-Laure Renoud, Jean Galitzky, Cecilia Holm, Etienne Mouisel, Claire Thalamas, Nathalie Viguerie, Thierry Sulpice, Rémy Burcelin, Peter Arner, Dominique Langin

HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors

Michael V. Airola, Nattakan Sukomon, Dipanjan Samanta, Peter P. Borbat, Jack H. Freed, Kylie J. Watts, Brian R. Crane

A Safeguard Mechanism Regulates Rho GTPases to Coordinate Cytokinesis with the Establishment of Cell Polarity

Franz Meitinger, Heidi Richter, Sabrina Heisel, Birgit Hub, Wolfgang Seufert, Gislene Pereira

A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

Oliver E. Farrance, Eleanore Hann, Renata Kaminska, Nicholas G. Housden, Sasha R. Derrington, Colin Kleanthous, Sheena E. Radford, David J. Brockwell

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

Simina Grigoriu, Rachel Bond, Pilar Cossio, Jennifer A. Chen, Nina Ly, Gerhard Hummer, Rebecca Page, Martha S. Cyert, Wolfgang Peti

Reciprocal Regulation of Protein Synthesis and Carbon Metabolism for Thylakoid Membrane Biogenesis

Alexandra-Viola Bohne, Christian Schwarz, Marco Schottkowski, Michael Lidschreiber, Markus Piotrowski, William Zerges, Jörg Nickelsen

Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains

Chen Wang, Jiayan Sang, Jiawei Wang, Mingyan Su, Jennifer S. Downey, Qinggan Wu, Shida Wang, Yongfei Cai, Xiaozheng Xu, Jun Wu, Dilani B. Senadheera, Dennis G. Cvitkovitch, Lin Chen, Steven D. Goodman, Aidong Han