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Table of Contents: January 2013

COVER

The fragmented Oxytricha trifallax macronuclear genome.

Image Credit: Estienne C. Swart and Laura F. Landweber
Issue Image

Oxytricha's two macronuclei (green) are shown schematically over a size-ranked map of some of its 16,000 tiny chromosomes. Alternatively processed chromosomes are shown in fuchsia and the 70 kb mitochondrial genome is shown in red for scale. Micronuclei are shown in dark blue. The macronuclear genome develops from the micronuclear genome by massive genome fragmentation and reassembly. See Swart et al. (e1001473) in this issue.

Synopses

Essay

Evolutionary Biology for the 21st Century

Jonathan B. Losos, Stevan J. Arnold, Gill Bejerano, E. D. Brodie III, David Hibbett, Hopi E. Hoekstra, David P. Mindell, Antónia Monteiro, Craig Moritz, H. Allen Orr, Dmitri A. Petrov, Susanne S. Renner, Robert E. Ricklefs, Pamela S. Soltis, Thomas L. Turner

Community Pages

Barcoding Life's Matrix: Translating Biodiversity Genomics into High School Settings to Enhance Life Science Education

Linda Santschi, Robert H. Hanner, Sujeevan Ratnasingham, Michelle Riconscente, Ralph Imondi

Science Incubators: Synthesis Centers and Their Role in the Research Ecosystem

Allen Rodrigo, Susan Alberts, Karen Cranston, Joel Kingsolver, Hilmar Lapp, Craig McClain, Robin Smith, Todd Vision, Jory Weintraub, Brian Wiegmann

Research Articles

The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes

Estienne C. Swart, John R. Bracht, Vincent Magrini, Patrick Minx, Xiao Chen, Yi Zhou, Jaspreet S. Khurana, Aaron D. Goldman, Mariusz Nowacki, Klaas Schotanus, Seolkyoung Jung, Robert S. Fulton, Amy Ly, Sean McGrath, Kevin Haub, Jessica L. Wiggins, Donna Storton, John C. Matese, Lance Parsons, Wei-Jen Chang, Michael S. Bowen, Nicholas A. Stover, Thomas A. Jones, Sean R. Eddy, Glenn A. Herrick, Thomas G. Doak, Richard K. Wilson, Elaine R. Mardis, Laura F. Landweber

Neurons Refine the Caenorhabditis elegans Body Plan by Directing Axial Patterning by Wnts

Katarzyna Modzelewska, Amara Lauritzen, Stefan Hasenoeder, Louise Brown, John Georgiou, Nadeem Moghal

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Roza Selimyan, Rachel M. Gerstein, Irina Ivanova, Patricia Precht, Ramesh Subrahmanyam, Thomas Perlot, Frederick W. Alt, Ranjan Sen

The Circadian Clock Coordinates Ribosome Biogenesis

Céline Jouffe, Gaspard Cretenet, Laura Symul, Eva Martin, Florian Atger, Felix Naef, Frédéric Gachon